ⓘ EIF4E

                                     

ⓘ EIF4E

Most eukaryotic cellular mRNAs are blocked at their 5-ends with the 7-methyl-guanosine five-prime cap structure, m7GpppX where X is any nucleotide. This structure is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. eIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of the eIF4F pre-initiation complex. Almost all cellular mRNA require eIF4E in order to be translated into protein. The eIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis.

Other units eIF4F is a 47-KD polypeptide, called eIF4A, that possesses ATPase and RNA helicase activities, as well as a 220-KD assembling polypeptide, eIF4G.

Some viruses cut eIF4G in such a way that the eIF4E binding site is removed and the virus is able to translate proteins without eIF4E. Also, in some cellular proteins, the most notable of which are heat shock proteins, do not require eIF4E in order to be translated. Both virus and cellular proteins to achieve this is through a site of internal entry of ribosomes on RNA.

                                     
  • translation initiation factor 4 E family member 3 is a protein that in humans is encoded by the EIF 4 E 3 gene. EIF 4 E 3 belongs to the EIF4E family of translational
  • mammalian eIF4E - related cap - binding protein J. Biol. Chem. 273 21 13104 9. doi: 10.1074 jbc.273.21.13104. PMID 9582349. Entrez Gene: EIF 4 E 2 eukaryotic
  • due to an alternate reading frame for the EIF 4 EBP3 segments. EIF 4 EBP3 has been shown to interact with EIF4E GRCh38: Ensembl release 89: ENSG00000243056
  • nuclear localization signal and nuclear export signals. EIF 4 ENIF1 has been shown to interact with EIF4E GRCh38: Ensembl release 89: ENSG00000184708 - Ensembl
  • behaviors. Knockout mice have high levels of Neuroligins. EIF 4 EBP2 has been shown to interact with EIF4E GRCh38: Ensembl release 89: ENSG00000148730 - Ensembl
  • scaffold protein that holds e IF 4 A and eIF4E together. The e IF 4 F complex is often accompanied by the accessory proteins e IF 4 B and e IF 4 H, either of which can
  • factor 4 F e IF 4 F which is a cap binding protein complex that consists of three subunits: e IF 4 A, eIF4E and e IF 4 G. The protein encoded by the e IF 4 G2 gene
  • initiation factor 4 E eIF4E in complex with 7 - methylguanosine diphosphate m7GDP and a 17 - amino acid peptide derived from human e IF 4 GII J. Biomol. NMR
  • The eukaryotic initiation factor - 4 A e IF 4 A family consists of 3 closely related proteins EIF 4 A1, EIF 4 A2, and EIF 4 A3. These factors are required for the
  • its dissociation from eIF4E and activation of cap - dependent mRNA translation. EIF 4 EBP1 has been shown to interact with: EIF4E KIAA1303, and Mammalian