Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 is an enzyme that in humans is encoded by the BUB1 gene.
Bub1-serine / treoninove protein kinase first identified in genetic screens of Saccharomyces cerevisiae. Protein bound kinetochores and plays a key role in the checkpoint of spindle and chromosome congression. Mitotic checkpoint kinase, evolutionary conserved in organisms as diverse as Saccharomyces cerevisiae and humans. With loss of function mutations or absence of Bub1 has been reported to lead to aneuploidy, chromosomal instability Cin and premature aging.