ⓘ Aromatase

                                     

ⓘ Aromatase

Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1, a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The enzyme aromatase can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, and bone, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development.

                                     
  • Aromatase inhibitors AIs are a class of drugs used in the treatment of breast cancer in postmenopausal women and gynecomastia in men. They may also
  • Steroidal aromatase inhibitors are a class of drugs that are mostly used for treating breast cancer in postmenopausal women. High levels of estrogen in
  • Aromatase deficiency is a very rare condition characterised by the extremely low or absence of the enzyme aromatase activity in the body. It is an autosomal
  • Non - Steroidal Aromatase Inhibitors NSAIs are one of two categories of aromatase inhibitors AIs AIs are divided into two categories, steroidal aromatase inhibitors
  • Aromatase excess syndrome AES or AEXS is a rare genetic and endocrine syndrome which is characterized by an overexpression of aromatase the enzyme
  • breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers
  • under the brand name Afema by Novartis is a selective, nonsteroidal aromatase inhibitor which is or has been used in Japan for the treatment of breast
  • metandroden, as well as 1 - methylandrosta - 1, 4 - diene - 3, 17 - dione, is a steroidal aromatase inhibitor that was studied in the treatment of cancer. It blocks the production
  • under the brand name Lentaron among others, is a steroidal, selective aromatase inhibitor which is used in the treatment of estrogen receptor - positive
  • such as cholesterol side - chain cleavage enzyme CYP11A1, P450scc and aromatase CYP19A1 thereby inhibiting the conversion of cholesterol into steroid