ⓘ TRAF5

                                     

ⓘ TRAF5

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor TRAF protein family and contains a meprin and TRAF homology MATH domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor TNF receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.

                                     
  • proteins have been characterized in mammals: TRAF 1, TRAF 2, TRAF 3, TRAF 4, TRAF5 TRAF 6 and TRAF 7. Except for TRAF 7, these proteins share a relatively conserved
  • NF - kappaB and stress - activated protein kinase c - Jun N - terminal kinase via TRAF 2, TRAF5 and NF - kappaB - inducing kinase J. Biol. Chem. 273 21 13353 8. doi: 10
  • NF - kappaB and stress - activated protein kinase c - Jun N - terminal kinase via TRAF 2, TRAF5 and NF - kappaB - inducing kinase The Journal of Biological Chemistry
  • interactions. The TNFR - receptor associated factor adaptor proteins TRAF 1, TRAF 2, TRAF 6 and possibly TRAF5 interact with this receptor serve as mediators of the signal
  • binds TRAF 2, 3 and 5 as well as PI3K by an unknown mechanism. TRAF 2 is required for survival via NF - κB and memory cell generation whereas TRAF5 seems
  • receptor is expressed by activated, but not by resting, T and B cells. TRAF 2 and TRAF5 can interact with this receptor, and mediate the signal transduction
  • that lead to the activation of NF - κB and MAPK8 JNK. Adaptor proteins TRAF 2 and TRAF5 have been shown to mediate the signaling process of this receptor.
  • receptor - associated factor 4 TRAF 4 also known as RING finger protein 83 RNF83 is a protein that in humans is encoded by the TRAF 4 gene. TRAF 4 is a member of the
  • encoded by the TRAF 1 gene. The protein encoded by this gene is a member of the TNF receptor TNFR associated factor TRAF protein family. TRAF proteins associate