ⓘ CUL1

                                     

ⓘ CUL1

Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination.

It is an essential component of SCF SKP1-CUL1-f-box protein E3 ubiquitin ligase complex, which mediates ubiquitination proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-f-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.

This protein is part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. It also interacts with RNF7. Part of a complex with TIP120A / CAND1 and RBX1. In the unneddylated form interacts with TIP120A / CAND1 and the interaction negatively regulates the Association with SKP1 in the SCF complex. Interacts with COPS2.

It is expressed in lung fibroblasts.

Neddylated protein, which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the CSN signalosome complex KC9.

                                     
  • Matsumoto T, Xiong Y 2003 NEDD8 modification of CUL1 dissociates p120 CAND 1 an inhibitor of CUL1 - SKP 1 binding and SCF ligases Mol. Cell. 10 6 1511 8
  • RBX1 has been shown to interact with: CAND1, CUL1 CUL 2, CUL 4A, CUL 5 CUL 7, DCUN 1 D 1 and P70 - S6 Kinase 1 GRCh38: Ensembl release 89: ENSG00000100387
  • 1 is a protein that in humans is encoded by the CAND 1 gene. CAND 1 has been shown to interact with: CUL1 CUL 2, CUL 3, CUL 4A, CUL 4B, DCUN 1 D 1 and RBX 1
  • genes CUL1 part of SCF complex CUL 2, part of ECS complex Elongin C - CUL 2 - SOCS - box CUL 3, part of CUL 3 - BTB complex CUL 4A CUL 4B CUL 5 CUL 7 CUL 9, also
  • T, Xiong Y Dec 2002 NEDD8 modification of CUL1 dissociates p120 CAND 1 an inhibitor of CUL1 - SKP 1 binding and SCF ligases Molecular Cell. 10 6
  • Fukuda M April 2001 In vitro ubiquitination of cyclin D 1 by ROC 1 - CUL1 and ROC 1 - CUL 3 FEBS Letters. 494 3 181 5. doi: 10.1016 S0014 - 5793 01 02343 - 2
  • C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ 2001 Promotion of NEDD - CUL1 conjugate cleavage by COP9 signalosome Science. 292 5520 1382 5. doi: 10
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  • Lykke - Andersen K, Wei N, Sun H, Kobayashi R, Zhang H 2003 CAND 1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex
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