ⓘ H3F3A

                                     

ⓘ H3F3A

Histone H3.3 is a protein that in humans is encoded by the H3F3A gene.

Histones-basic nuclear proteins that are responsible for the structure of the nucleosomes of the chromosomal fiber in eukaryotes. Two molecules each of four core histones form an octamer, around which approximately 146 BP of DNA is wrapped in repeating units, called nucleosomes. Histone H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene includes its introns are not and there the mRNA, unlike most histone genes. The protein encoded is a replication-independent member of a family of histone H3.

H3F3A mutations are also associated with certain types of cancer. S. Lys27Met was discovered in the inner tumor of the Pons DIPG, where they are present in 65-75% of tumors and leads to unfavorable prognosis. S. Lys27Met changes in HIST1H3B and HIST1H3C that the code of histone H3.1 have also been reported in ~10% of DIPG. H3F3A is also mutated in a minority of children and young astrocytoma class for adults, but more often C. Gly34Arg / Shaft. Mutations in H3F3A and H3F3B also found in chondroblastoma and giant cell tumor of bone.

                                     
  • Futreal PA, Stratton MR, Campbell PJ, Flanagan AM Dec 2013 Distinct H3F3A and H 3 F 3 B driver mutations define chondroblastoma and giant cell tumor of bone
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