ⓘ ADH1B

                                     

ⓘ ADH1B

Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene.

The protein encoded by this gene is a member of a family of dehydrogenases of alcohol. The members of this family of enzyme metaboliziruet various substrates, including ethanol, alcoholic beverage, retinol, other aliphatic alcohols, hydroxysteroids, and products of lipid peroxidation. The encoded protein, known as ADH1B or beta-ADH, can form homodimers and heterodimer with the ADH1A and ADH1C units, shows high activity in the oxidation of ethanol plays an important role in the catabolism of ethanol to oxidize ethanol to acetaldehyde. Acetaldehyde is then metabolised to acetate genes of the aldehyde dehydrogenase. Three genes encoding related alpha, beta and gamma subunits are tandemly organized in a genomic segment of the genome.

The human gene is located on chromosome 4 in 4q22.

ADH1B was previously called ADH2. There are more genes in the family of alcohol dehydrogenase. These genes are now referred to as ADH1A, ADH1C, and ADH4, ADH5, ADH6 and ADH7.

                                     
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  • SE, Wall TL 2007 ALDH2, ADH1B and ADH 1 C genotypes in Asians: a literature review Alcohol Research Health. 30 1 22 7. PMC 3860439. PMID 17718397
  • Luczak, SE Wall, TL 2007 ALDH2, ADH1B and ADH 1 C genotypes: A literature review Alcohol Research Health. 30 1 22 7. PMC 3860439. PMID 17718397
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