ⓘ CAPN10

                                     

ⓘ CAPN10

Calpain-10 is a protein that in humans is encoded by the CAPN10 gene.

Calpain present, well-preserved family of calcium-dependent, cysteine proteases. Typical calpain protein heterodimer, consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: a domain N-terminal regulatory domain that is processed upon calpain activation, the second domain, a protease domain III, a linker domain of unknown function, and domain IV, the calmodulin-calcium binding domain. The heterodimer interface is predominantly found between domain IV and the small subunit, which is calmodulin-calcium binding domain. This gene encodes the large subunit. It is an atypical calpain in that it lacks the calmodulin-calcium binding domain and is divergent C-terminal domain. It therefore cannot heterodimerize with the small subunit. It is similar in organization to calpain 5 and 6. This gene is associated with type 2 or non-insulin dependent diabetes mellitus NIDDM and is located in the region of NIDDM1. Several alternative transcripts encoding different isoforms have been described for this gene.