ⓘ PDE4D

                                     

ⓘ PDE4D

The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells Dominiczak and McBride, 2003.

                                     
  • types of the enzyme phosphodiesterase 4 PDE 4 are known: PDE 4 A PDE 4 B PDE 4 C PDE4D 3 5 - cyclic - AMP phosphodiesterase Phosphodiesterase PDE 4 inhibitor
  • arthritis. PDE4D inhibition, along with PDE 4 A inhibition also appears to be responsible for the antidepressant effects of PDE 4 inhibitors. Similarly PDE 4 B inhibition
  • and rat genes PDE4D and PDE 4 B encoding the cAMP - specific phosphodiesterases 3 and 4 Cytogenetics and Cell Genetics. 69 1 2 11 4 doi: 10.1159 000133927
  • 4 A is an enzyme that in humans is encoded by the PDE 4 A gene. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase PDE
  • The co - crystal structures for PDE 4 B, PDE4D and PDE 5A have revealed two common features of inhibitor binding to PDEs One is a planar ring structure
  • implicated in human brain size evolution. Myomegalin PDE 4 DIP has been shown to interact with PDE4D The protein was discovered in 2000 and was so named
  • encoded by the PDE 6 D gene. PDE 6 D was originally identified as a fourth subunit of rod cell - specific cGMP phosphodiesterase PDE EC 3.1. 4 35 The precise
  • parts: A saddle formed by the conserved glutamine Q817 in PDE 5A, Q443 in PDE 4 B and Q369 in PDE4D and the P clamp a hydrophopic clamp at the narrow side
  • cAMP - specific 3 5 - cyclic phosphodiesterase 4 C is an enzyme that in humans is encoded by the PDE 4 C gene. PDE 4 C is predominantly found in peripheral tissues
  • phosphodiesterase type 5 inhibitor PDE 5 inhibitor is a drug used to block the degradative action of cGMP - specific phosphodiesterase type 5 PDE 5 on cyclic GMP in the
  • subunit beta is the beta subunit of the protein complex PDE 6 that is encoded by the PDE 6B gene. PDE 6 is crucial in transmission and amplification of visual