ⓘ EIF4EBP1

                                     

ⓘ EIF4EBP1

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E eIF4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5 end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of cap-dependent mRNA translation.

                                     
  • translation initiation factor 4 E - binding protein 2 is a protein that in humans is encoded by the EIF 4 EBP 2 gene. EIF 4 EBP 2 knockout mice have been used
  • eIF 4 E and CYFIP 1 allowing for the initiation of translation. EIF 4 E has been shown to interact with: EIF 4 A 1 EIF4EBP1 EIF 4 EBP 2, EIF 4 EBP 3, EIF 4 ENIF 1 EIF4G1
  • Eukaryotic initiation factor 4 A - I also known as eIF 4 A 1 or DDX2A is a 46 kDa cytosolic protein that in humans is encoded by the EIF 4 A 1 gene, which, in humans
  • factor 4 E EIF 4 E by mTOR suppresses the capacity of Eukaryotic translation initiation factor 4 E - binding protein 1 EIF4EBP1 to inhibit EIF 4 E and slow
  • initiation factor 2A eIF2A is a protein that in humans is encoded by the EIF 2A gene. The eIF2A protein is not to be confused with eIF2α, a subunit of
  • sacral chordomas exhibited phosphorylation of Ribosomal protein s6 and EIF4EBP1 by immunohistochemistry Partial or complete PTEN gene deficiency is observed
  • domain. Co - transcription of this gene and the neighboring downstream gene EIF 4 EBP 3 generates a transcript MASK - BP3 which encodes a fusion protein composed
  • Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4 A Translation. 4 1 e1137381. doi: 10.1080 21690731.2015.1137381. PMC 4909409. PMID 27335721
  • activated, it can phosphorylate downstream targets such as p70S6K, 4 EBP and ULK 1 which are important for regulating protein anabolic catabolic balance
  • binds to 4 EBP 1 and RPS6KB 1 directly whether or not it is associated with mTOR RPTOR binds to poorly phosphorylated or non - phosphorylated EIF4EBP1 preferentially
  • Five different genes, Eif 4 a 1 Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11 Gene. 237 1 53 60. doi: 10