Cardiac muscle troponin T is a protein that in humans is encoded by the TNNT2 gene. Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.
TNNT2 gene is located at 1q32 in the genome of human chromosomes, encoding the heart muscle isoform of troponin T cTnT. Human cTnT is a ~36 KDA protein consisting of 297 amino acids including the first methionine with the isoelectric point of intersection of 4.88. This is the tropomyosin - binding and thin filament anchoring subunit of the troponin complex in heart muscle cells. TNNT2 gene expressed in vertebrate cardiac muscle and fetal skeletal muscle.
- ssTnT encoded by TNNT 1 and cardiac TnT cTnT encoded by TNNT2 Structure of fsTnT is conserved among vertebrate species Fig. 2 reflecting specialized
- troponin T sTnT is a protein that in humans is encoded by the TNNT 1 gene. The TNNT 1 gene is located at 19q13.4 in the human chromosomal genome, encoding
- Slow skeletal troponin T1, TNNT 1 19q13.4, 191041 Cardiac troponin T 2 TNNT2 1q32, 191045 Fast skeletal troponin T3, TNNT 3 11p15.5, 600692 The 99th
- with Dilated cardiomyopathy. They also added that there was a fault in the TNNT2 Gene which was the cause of all their heart related problems. In July 2008
- protein 63A TNFSF18 1q25 TNN 1q25 TNNT2 cardiac troponin T 2 TOR1AIP1: Torsin - 1A - interacting protein 1 TP53BP 2 1q41 TRE - CTC1 - 5: Transfer RNA - Glu CTC
- with the fast twitch skeletal muscle and cardiac TnI isoform genes TNNT2 and TNNT 3 TNNI1 has a broader range of expression in avian and mammalian striated
- of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2 TCAP, and PLN Clinical Cardiology. 36 10 628 33. doi: 10.1002 clc.22193
- Binding Protein C MYBPC3 Myosin Heavy Chain 7 MYH7 Cardiac Troponin T 2 TNNT2 and Cardiac Troponin I TNNI3 They also reviewed recent studies investigating
- Institute of Chemistry. 85: 429. doi: 10.1039 JI9618500429. Smithson Tennant TNNT 782S A Cambridge Alumni Database. University of Cambridge. Smithson Tennant
- muscle is required for growth and postnatal survival: characterization of Tnnt 3 tm 2 a KOMP Wtsi mice Genesis. 51 9 667 75. doi: 10.1002 dvg.22407. PMC 3787964