ⓘ TSG101

                                     

ⓘ TSG101

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.

The main role of ESCRT-I must admit ubiquitinates of goods through the UEV domain protein VPS23 / TSG101 subunit. The Assembly of the ESCRT-I complex is directed to C-terminal steadiness box SB VPS23, the N-terminal half of VPS28, and the C-terminal half of VPS37. The structure basically consists of three long, parallel helical hairpins, each corresponding to a different subunit. Additional domains and motifs extending beyond the major to serve as gripping tools for ESCRT-I critical functions.

                                     
  • protein sorting 23 VPS23 also known as tumor susceptibility gene 101 TSG101 and vacuolar protein sorting 37 VPS37 Two alternative transcripts
  • E3 ubiquitin - protein ligase LRSAM1, previously known as Tsg101 - associated ligase Tal is an enzyme that in humans is encoded by the LRSAM1 gene. Mutations
  • through their interaction with specific host cellular proteins, such as tsg101 and vps - 4. VP40 coordinates numerous functions in the viral life cycle of
  • Venezuelan equine encephalitis virus. The drug acts by inhibiting the protein TSG101 which transports newly manufactured virions to the exterior of an infected
  • DLG4, EPS15, IL2RB, Merlin, STAM2, Signal transducing adaptor molecule TSG101 PDBe - KB provides an overview of all the structure information available
  • The 2019 20 season is TSG 1899 Hoffenheim s 121st season in existence and the club s 12th consecutive season in the top flight of German football. It
  • penta - EF - hand protein ALG - 2 interacts directly with the ESCRT - I component TSG101 and Ca2 - dependently co - localizes to aberrant endosomes with dominant - negative
  • et al. 2004 Physical and functional interactions between Daxx and TSG101 Biochem. Biophys. Res. Commun. 316 3 827 33. doi: 10.1016 j.bbrc.2004
  • Veettil, Mohanan Valiya Chandran, Bala October 2016 ESCRT - I Protein Tsg101 Plays a Role in the Post - macropinocytic Trafficking and Infection of Endothelial
  • J 1998 Role of UEV - 1A, a homologue of the tumor suppressor protein TSG101 in protection from DNA damage FEBS Lett. 423 1 49 52. doi: 10