ⓘ NPM1

                                     

ⓘ NPM1

NPM1 is associated with nucleolar ribonucleoprotein structures and binds single-stranded and double-stranded nucleic acids, but it binds preferentially G-quadruplex forming nucleic acids. It is involved in the biogenesis of ribosomes and may assist small basic proteins in their transport to the nucleolus. Its regulation through SUMOylation by SENP3 and SENP5 is another facet of the proteinss regulation and cellular functions.

It is located in the nucleolus, but it can be moved with the enlightenment nucleoplasm in the case of serum starvation or treatment with anticancer agents. Protein fosfauriliruetsa.

Nucleophosmin has several functions:

  • Prevents apoptosis when located in nucleolus.
  • Ribosome biogenesis and transport.
  • Regulation of ARF-p53 tumor suppressor pathway.
  • Histone chaperones. (Гистоновых шаперонов)
  • Genomic stability and DNA repair.
  • Centrosome duplication during cell cycle.
  • RNA helix destabilizing activity.
  • Inhibition of caspase-activated DNase.
  • Endoribonuclease activity. (Деятельность Endoribonuclease)
                                     
  • npm originally short for Node Package Manager is a package manager for the JavaScript programming language. It is the default package manager for the
  • homologous to the murine Npm 3 gene. Based on the structural similarity of the human NPM 3 gene product to nucleoplasmin and nucleophosmin, NPM 3 may represent a
  • B23 may refer to: a human nucleolar protein also known as NPM1 the 2.3L, pre - revision variant of the Volvo Redblock engine BundesstraSe 23, federal highway
  • belongs to the Ulp 1 branch in yeast and localize to nucleolus through B23 NPM1 SENP3 is associated and regulated by B23 nucleophosmin NPM1 and involved in
  • members of the nucleoplasmin family: Nucleophosmin NPM1 Nucleoplasmin 2 NPM 2 Nucleoplasmin 3 NPM 3 C, Dingwall RA., Laskey Feb 1990 Nucleoplasmin:
  • NGC 77 also known as PGC 1290, NPM 1 G - 22.0006 or PGC 198147 is a lenticular galaxy located 780 million light - years away in the constellation of Cetus
  • co - complex interactions. COX8A appears to interact with NPM1 MAGEA4, EDDM3B, BATF, AMBP, CREB 1 and NCOR 1 GRCh38: Ensembl release 89: ENSG00000176340 - Ensembl
  • received if the NPM had been an SPM. The originally enacted escrow statutes permitted an NPM to obtain a refund of the amount the NPM paid into the escrow
  • Mar 1996 The t 3 5 q25. 1 q34 of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM - MLF 1 Oncogene. 12 2 265 75
  • and NPM1 Essential for localization of MAD2L 1 to kinetochore and MAPK 1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G 1 S - arrested