ⓘ PRKCE

                                     

ⓘ PRKCE

Protein kinase C epsilon type is an enzyme that in humans is encoded by the PRKCE gene. PKCε is an isoform of the large PKC family of protein kinases that play many roles in different tissues. In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. PKCε is clinically significant in that it is a central player in cardioprotection against ischemic injury and in the development of cardiac hypertrophy.

                                     
  • DGKZ GMIP HMHA1 KSR1 KSR2 MYO9A MYO9B PDZD8 PRKCA PRKCB1 PRKCD PRKCE PRKCG PRKCH PRKCI PRKCN PRKCQ PRKCZ PRKD1 PRKD2 PRKD3 RACGAP1
  • are affected. Keratin 1 has been shown to interact with Desmoplakin and PRKCE 34βE12 GRCh38: Ensembl release 89: ENSG00000167768 - Ensembl, May 2017
  • PLCE1 PLCG1 PLCG2 PLCH1 PLCH2 PLCL1 PLCL2 PLCZ1 PRF1 PRKCA PRKCB1 PRKCE PRKCG PRKCH RAB11FIP1 RAB11FIP2 RAB11FIP5 RASA1 RASA2 RASA3 RASA4
  • steroids. Actin, alpha 1 has been shown to interact with TMSB4X, MIB2 and PRKCE Actin ACTB GRCh38: Ensembl release 89: ENSG00000143632 - Ensembl, May 2017
  • PRKCG novel - require DAG but not Ca2 for activation PKC - δ PRKCD PKC - ε PRKCE PKC - η PRKCH PKC - θ PRKCQ atypical - require neither Ca2 nor DAG for
  • Cyclin A1 EIF6, FYN, IFNAR2, Janus kinase 1 OTUB1, P73, PDE4D, PRKCB1, PRKCE PTPRM, RAS p21 protein activator 1, ST7, STAT1, Src, and Tyrosine kinase
  • POMK  PRKAA1  PRKAA2  PRKACA  PRKACB  PRKACG  PRKCA  PRKCB  PRKCD  PRKCE PRKCG  PRKCH  PRKCI  PRKCQ  PRKCZ  PRKD1  PRKD2  PRKD3  PRKG1 
  • and protein kinase C beta i.e. PRKCB1, delta i.e. PRKCD epsilon i.e. PRKCE and zeta i.e. PRKCZ OXER1 is activated by 5 - oxo - ETE, 5 - HETE, and other
  • interact with: BCL2 - like 1, Bcl - 2 - associated X protein, DYNLT3, Gelsolin, PRKCE HK1 Parkin eNOS Mcl - 1 HK ATP Voltage - dependent anion channel GRCm38: Ensembl
  • conductance regulator has been shown to interact with: DNAJC5, GOPC, PDZK1, PRKCE SLC4A8, SNAP23, SLC9A3R1, SLC9A3R2, and STX1A, It is inhibited by the anti - diarrhoea
  • BCAR1, BAX, BAD, C - Raf, CDC25B, GP1BA, GP1BB, HMGN1, IL9R, LIMK1, P53, PRKCE PRKCZ, TNFAIP3, TSC2, Tau protein, and VIM. 14 - 3 - 3 protein GRCh38: Ensembl
  • abnormalities were observed in these animals. MYH9 has been shown to interact with PRKCE May Hegglin anomaly GRCh38: Ensembl release 89: ENSG00000100345 - Ensembl