ⓘ HDAC3

                                     

ⓘ HDAC3

Histones are highly alkaline proteins that package and order DNA into structural units called nucleosomes, which comprise the major protein component of chromatin. The posttranslational and enzymatically mediated lysine acetylation and deacetylation of histone tails changes the local chromatin structure through altering the electrostatic attraction between the negatively charged DNA backbone and histones. HDAC3 is a Class I member of the histone deacetylase superfamily comprising four classes based on function and DNA sequence homology that is recruited to enhancers to modulate both the epigenome and nearby gene expression. HDAC3 is found exclusively in the cell nucleus where it is the sole endogenous histone deacetylase biochemically purified in the nuclear-receptor corepressor complex containing NCOR and SMRT NCOR2. Thus, HDAC3 unlike other HDACs, has a unique role in modulating the transcriptional activities of nuclear receptors.

                                     
  • with the class I HDAC HDAC3 in order to suppress gene expression. It has been demonstrated through crystal structures of the human HDAC 7 that the catalytic
  • bipolar cells in the retinas of mice. HDAC 4 has been shown to interact with: BCL6, BTG2, CBX5, GATA1, HDAC3 MAPK1, MAPK 3 MEF2C, Myocyte - specific enhancer
  • Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT N - CoR Mol. Cell. 9 1 45 57. doi: 10
  • Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT N - CoR Molecular Cell. 9 1 45 57
  • determined. HDAC 9 has been shown to interact with: CBX5, HDAC3 BTG2, Myocyte - specific enhancer factor 2A Nuclear receptor co - repressor 1, SIN 3 A, and SUV39H1
  • deacetylation via HDAC3 and HDAC 6. These are just some examples of constantly emerging non - histone, non - chromatin roles for HDACs Inherited mutations
  • uniqueness to each HDAC as well as regulatory cross - talk between factors. HDAC3 has been found to be most closely related to HDAC 8. HDAC3 contains a non - conserved
  • chromosome TBL1Y gene. TBL1X has been shown to interact with: GPS2, and HDAC3 NCOA1, and NCOA2. GRCh38: Ensembl release 89: ENSG00000101849 - Ensembl
  • Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT N - CoR Molecular Cell. 9 1 45 57
  • trials for treatment of various cancers. Entinostat inhibits class I HDAC 1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively. Syndax pharmaceuticals