ⓘ RASSF1

                                     

ⓘ RASSF1

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

                                     
  • isoforms have been found for this gene. RASSF 5 has been shown to interact with RRAS, RAP2A, MRAS and RASSF1 GRCh38: Ensembl release 89: ENSG00000266094
  • Microtubule - associated protein 1 S is a protein that in humans is encoded by the MAP 1 S gene. MAP 1 S has been shown to interact with RASSF1 GRCh38: Ensembl release
  • association domain - containing protein 9 RASSF 9 also known as PAM COOH - terminal interactor protein 1 PCIP 1 or peptidylglycine alpha - amidating monooxygenase
  • also play a role in a MAPK - independent pathway. CNKSR 1 has been shown to interact with RhoD and RASSF1 GRCh38: Ensembl release 89: ENSG00000142675 - Ensembl
  • domain - containing protein 2 is a protein that in humans is encoded by the RASSF 2 gene. This gene encodes a protein that contains a Ras association domain
  • domain - containing protein 8 is a protein that in humans is encoded by the RASSF 8 gene. GRCh38: Ensembl release 89: ENSG00000123094 - Ensembl, May 2017 GRCm38:
  • PRKCZ PRKD 1 PRKD2 PRKD3 RACGAP 1 RAF 1 RASGRP RASGRP 1 RASGRP2 RASGRP3 RASGRP4 RASSF1 RASSF 5 ROCK 1 ROCK2 STAC STAC2 STAC3 TENC 1 UNC13A
  • have been described. MAP 1 B has been shown to interact with Acidic leucine - rich nuclear phosphoprotein 32 family member A and RASSF1 GRCh38: Ensembl release
  • MICROTUBULAR CYTOSKELETON WITH CHROMOSOME REMODELING AND TUMOR SUPPRESSOR RASSF1 DEDUCED BY IN SILICO HOMOLOGY ANALYSIS, INTERACTION CLONING IN YEAST, AND