ⓘ Cholesterol 24-hydroxylase
Cholesterol 24-hydroxylase, also commonly known as cholesterol 24S-hydroxylase, cholesterol 24-monooxygenase, CYP46, or CYP46A1, is an enzyme that catalyzes the conversion of cholesterol to 24S-hydroxycholesterol. It is responsible for the majority of cholesterol turnover in the human central nervous system. The systematic name of this enzyme class is cholesterol,NADPH:oxygen oxidoreductase.
This enzyme is a member of the cytochrome P450 test CYP superfamily of enzymes. Like many other CYP enzymes that act on cholesterol, Cholesterol-24 hydroxylase is a monooxygenase that hydroxylates the side chain of cholesterol.
After all, 24S-hydroxycholesterol is more polar than cholesterol, it can more easily pass through the blood-brain barrier to leave the brain and pass into the bloodstream where it can travel to the liver to be even more humiliated. This enzyme has been found in small quantities in the retina, where it performs the same function to a lesser degree.
Genetic cloning of the gene encoding CYP46A1 was first recorded in 1999 and later had extensive E. coli expression and purification system developed in 2003.