ⓘ Glutathione S-transferase Mu 1

                                     

ⓘ Glutathione S-transferase Mu 1

Cytosolic and membrane-bound forms of glutathione S -transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S -transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S -transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione.

Genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3, and are known to be highly polymorphic. These genetic variations may modify the susceptibility of individuals to carcinogens and toxins as well as affect the toxicity and efficacy of some medications. Null mutations of this gene of the mu class have been associated with an increase in the number of cancers, likely due to increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

                                     
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  • glutathione S - transferases have been identified: alpha, kappa, mu omega, pi, sigma, theta, and zeta. This gene encodes a glutathione S - transferase that
  • Glutathione S - transferase Mu 4 is an enzyme that in humans is encoded by the GSTM4 gene. Cytosolic and membrane - bound forms of glutathione S - transferase
  • mammalian glutathione S - transferases have been identified: alpha, kappa, mu omega, pi, sigma, theta and zeta. This gene encodes a glutathione S - transferase belonging
  • Glutathione S - transferase theta - 2 is an enzyme that in humans is encoded by the GSTT2 gene. Glutathione S - transferase GSTs theta 2 GSTT2 is a member