ⓘ STIM1

                                     

ⓘ STIM1

Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. STIM1 has a single transmembrane domain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane.

Even if the protein has been previously defined, its function was unknown until recently. In 2005 it was discovered that STIM1 functions as a calcium sensor in the endoplasmic reticulum. When activated, the IP3 receptor, the calcium concentration in the endoplasmic reticulum decreases, which is perceived by STIM1, via its EF hand domain. STIM1 activates the "store fixture" ORAI1 calcium ion channels in the plasma membrane, via intracellular movement of STIM1, clustering under the plasma membrane and the interaction of the protein with ORAI isoforms. STIM1-mediated calcium entry is required for thrombin-induced disassembly of ve-cadherin adherens connection. 2-Aminoethoxydiphenyl borate 2-APB and 4-chloro-3-ethylphenol 4-ser cause STIM1 clustering in cells and prevent STIM1 moves to the plasma membrane.

                                     
  • Ca2 signaling in non - electrically excitable cells. While STIM1 triggers SOCE, research on STIM 2 function suggests a major role as feedback regulator that
  • cells from Ca2 overfilling. Cation diffusion facilitator ORAI 1 ORAI2 STIM1 STIM 2 TRPC 1 Transporter Classification Database Matias MG, Gomolplitinant
  • calcium concentration in the endoplasmic reticulum is sensed by the STIM1 protein. STIM1 clusters upon the depletion of the calcium stores and forms puncta
  • peptide and the transmembrane domain derived from STIM1 with GFP placed in between as a reporter. STIM1 is an ER - resident calcium sensor protein responsible
  • mediated by the STIM - ORAI signaling in vertebrates. STIMATE can physically associate with STIM1 to promote conformational switch of STIM1 from inactive
  • configuration with the stromal interaction molecule 1 gene STIM1 with the 3 end of STIM1 situated 1 6 kb from the 5 end of this gene. Click on genes
  • Choi M, Richardson AS, Reid BM, Seymen F, Yildirim M, et al. July 2014 STIM1 and SLC24A4 Are Critical for Enamel Maturation Journal of Dental Research
  • currently still under investigation, although two candidate molecules, Orai 1 and STIM1 have been linked by several studies, and a model of store - operated calcium
  • shown that tyrosine phosphorylation of VE - PTP via Pyk2 kinase downstream of STIM1 - induced calcium entry mediates disassembly of the endothelial adherens junctions
  • stromal interaction molecules STIMs and Orais, however, have more recently been implicated in this process. STIM1 and TRPC 1 can coassemble, complicating
  • CALCIUM - SELECTIVE CURRENTS DUE TO CO - EXPRESSION OF ORAI 1 OR ORAI2 WITH THE INTRACELLULAR CALCIUM SENSOR, STIM1 J. Biol. Chem. 281 34 24979 90. doi: 10.1074 jbc