ⓘ MAPK8

                                     

ⓘ MAPK8

The protein encoded by this gene is a member of the MAP kinase and JNK family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha TNF-alpha is found to be required for TNF-alpha-induced apoptosis. This kinase is also involved in UV radiation-induced apoptosis, which is thought to be related to the cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternately spliced transcript variants encoding distinct isoforms have been reported.

                                     
  • diabetes. MAPK 8 IP1 has been shown to interact with MAP3K10, DUSP16, Mitogen - activated protein kinase 9, MAPK8 LRP2, LRP1, MAP3K12, MAP2K7, MAPK 8 IP2 and
  • cells. It has been shown to interact with, and regulate the activity of MAPK8 JNK1, and MAP2K7 MKK7 kinases. This protein thus is thought to function
  • kinase 15, also known as MAPK 15, ERK7, or ERK 8 is an enzyme that in humans is encoded by the MAPK 15 gene. Evolutionarily, MAPK 15 is conserved in a number
  • determined. MAPK 8 IP3 has been shown to interact with ASK1, C - Raf, PTK2, MAPK 10, Mitogen - activated protein kinase 9, MAPK8 MAP2K1, KLC2, MAP2K7, KLC1, MAPK 8 IP2
  • Mitogen - activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK 4 gene. Mitogen - activated protein kinase 4 is a member of the mitogen - activated
  • Mitogen - activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK 6 gene. The protein encoded by this gene is a member of the Ser Thr protein
  • which activate the ERK1 2 MAPK 3 MAPK 1 pathway, through activation of MEK1 MAP2K1 and MEK2 MAP2K2 MEKK1 activates MAPK8 JNK by phosphorylation of its
  • expression in response to various cell stimuli. It is most closely related to MAPK8 both of which are involved in UV radiation - induced apoptosis, thought to
  • Mitogen - activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK 11 gene. The protein encoded by this gene is a member of the MAP kinase family
  • Mitogen - activated protein kinase 1, also known as MAPK 1, p42 MAPK and ERK2, is an enzyme that in humans is encoded by the MAPK 1 gene. The protein encoded by this gene
  • to MAPK 14 for p38α MAPK the p38 MAPK family has three additional members, including MAPK 11, MAPK 12 and MAPK 13 which encodes p38β MAPK p38γ MAPK and
  • protein kinase 13 MAPK 13 also known as stress - activated protein kinase 4 SAPK4 is an enzyme that in humans is encoded by the MAPK 13 gene. The protein