ⓘ Small ubiquitin-related modifier 1

                                     

ⓘ Small ubiquitin-related modifier 1

This gene encodes a protein that is a member of the SUMO small ubiquitin-like modifier protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin, which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.

Most splitting of component gene samoilivna. Analysis of chromosomal abnormalities in patients led to the identification and confirmation of SUMO1 as cleft lip and palate locus.

                                     
  • point in the field, with the discovery of SUMO small ubiquitin - like modifier also known as Sentrin or SENP 1 reported around the same time by a variety
  • ThiS, with its E 1 - like enzyme ThiF. It is also believed that the Saccharomyces cerevisiae protein Urm - 1 a ubiquitin - related modifier is a molecular
  • transfer of SUMO protein to other proteins The Small Ubiquitin - related Modifier SUMO - 1 is a ubiquitin - like family member that is conjugated to its substrates
  • such as SENP6, prior to their conjugation to target proteins small ubiquitin - related modifier 1 GRCh38: Ensembl release 89: ENSG00000112701 - Ensembl, May
  • maintenance of spermatogenesis. PIAS 1 has been shown to interact with: DNMT3A, P53, STAT 1 Small ubiquitin - related modifier 1 Sp3 transcription factor, and
  • the small ubiquitin - like modifier SUMO propeptide, Smt3 The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin - like modifier 1 SUMO - 1
  • Small ubiquitin - related modifier 2 is a protein that in humans is encoded by the SUMO2 gene. This gene encodes a protein that is a member of the SUMO small
  • Small ubiquitin - related modifier 4 is a protein that in humans is encoded by the SUMO4 gene. This gene is a member of the SUMO gene family. This family
  • Small ubiquitin - related modifier 3 is a protein that in humans is encoded by the SUMO3 gene. SUMO proteins, such as SUMO3, and ubiquitin see MIM 191339
  • localization sequence. SAE2 has been shown to interact with SAE 1 Small ubiquitin - related modifier 1 and UBE2I. GRCh38: Ensembl release 89: ENSG00000126261
  • Small Ubiquitin - like Modifier or SUMO proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells
  • tagged for degradation with a small protein called ubiquitin The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged