ⓘ Transforming protein RhoA

                                     

ⓘ Transforming protein RhoA

Transforming protein RhoA, also known Ras homolog family member A, is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the RHOA gene. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them, ROCK1 and DIAPH1 are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billion years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution. RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation.

                                     
  • Yang, Xu - Yu et al. p120Ras - GAP Binds the DLC1 Rho - GAP Tumor Suppressor Protein and Inhibits Its RhoA GTPase and Growth Suppressing Activities Oncogene
  • 2002 Rho B, not RhoA represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1
  • Leukemia - associated Rho guanine nucleotide exchange factor LARG Rho guanine nucleotide exchange factor 12 is guanine nucleotide exchange factor GEF for the RhoA small
  • G protein - coupled receptors GPCRs also known as seven - pass - transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor
  • Protein ECT2 is a protein that in humans is encoded by the ECT2 gene. The protein encoded by this gene is a transforming protein that is related to Rho - specific
  • functional domain protein is a protein that in humans is encoded by the TRIO gene. TRIO gene has been shown to interact with Filamin and RHOA GRCh38: Ensembl
  • ARHGEF13 Rho GEF13 because it contains a guanine nucleotide exchange factor GEF domain for the RhoA small GTP - binding protein A - kinase anchor protein 13 Rho
  • siRNAs that targeted RhoA had no effect on other members of the Rho family. Further analysis showed that PRK2, a direct target of Rho is required for the
  • Neuroepithelial cell - transforming gene 1 protein is a protein that in humans is encoded by the NET1 gene. GRCh38: Ensembl release 89: ENSG00000173848
  • RhoGEF11 or PDZ - Rho GEF. Rho guanine nucleotide exchange factor 11 is guanine nucleotide exchange factor GEF for the RhoA small GTPase protein Rho is a small
  • The predicted DBL oncogene product defines a distinct class of transforming proteins Proceedings of the National Academy of Sciences of the United