ⓘ WNT4

                                     

ⓘ WNT4

WNT4 is a secreted protein that in humans is encoded by the Wnt4 gene, found on chromosome 1. It promotes female sex development and represses male sex development. Loss of function can have serious consequences, such as female to male sex reversal.

                                     
  • WNT4 deficiency is a rare genetic disorder that affects females and it results in the underdevelopment and sometimes absence of the uterus and vagina.
  • The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors
  • SHH - N upregulates Sfrp2 to mediate its competitive interaction with WNT 1 and WNT4 in the somitic mesoderm Development. 127 1 109 18. PMID 10654605
  • development. Other members of the WNT family that are required for the development of the reproductive tract are Wnt4 and Wnt 7a. Failure to develop reproductive
  • Ceratizit WNT Pro Cycling UCI code WNT is a professional women s cycling team, based in Kempten, Germany, which competes in elite road bicycle racing
  • autosomal recessive disorder in XX humans. It is caused by loss of function in WNT4 a protein involved in sex development. The main outcome is female to male
  • Protein Wnt - 9a formerly Wnt 14 is a protein that in humans is encoded by the WNT 9A gene. The WNT gene family consists of structurally related genes that
  • with WNT4 in the process of female sex development. Loss of function can cause female to male sex reversal. Furthermore, it promotes canonical WNT β catenin
  • Protein Wnt - 10b formerly Wnt 12 is a protein that in humans is encoded by the WNT 10B gene. The WNT gene family consists of structurally related genes
  • Protein Wnt - 2b formerly Wnt 13 is a protein that in humans is encoded by the WNT 2B gene. This gene encodes a member of the wingless - type MMTV integration
  • domain - binding motif. The FZD6 protein is believed to be the receptor for the WNT4 ligand. FZD6 has been shown to interact with Secreted frizzled - related protein