ⓘ Internexin

                                     

ⓘ Internexin

Internexin, alpha-internexin, is a Class IV intermediate filament approximately 66 KDa. The protein was originally purified from rat optic nerve and spinal cord. The protein copurifies with other neurofilament subunits, as it was originally discovered, however in some mature neurons it can be the only neurofilament expressed. The protein is present in developing neuroblasts and in the Central Nervous System of adults. The protein is a major component of the intermediate filament network in small interneurons and cerebellar granule cells, where it is present in the parallel fibers.

                                     
  • protein GFAP Type IV consists of the neurofilament proteins L, M, H and internexin Type V consists of the nuclear lamins, and type VI consists of the protein
  • medium NF - M and light neurofilament NF - L proteins, nestin and α - internexin in nerve cells, synemin α and desmuslin synemin β two alternative transcripts
  • Golbeck A, et al. 2002 Novel products of the HUD, HUC, NNP - 1 and alpha - internexin genes identified by autologous antibody screening of a pediatric neuroblastoma
  • the cytoplasm, and transmit membrane receptor signals to the nucleus. α - Internexin Neurofilaments - the type IV family of intermediate filaments that is
  • these experiments, peripherin deficiency did produce an upregulation of α - internexin indicating the possibility that this type IV intermediate filament makes
  • Golbeck A, et al. 2002 Novel products of the HUD, HUC, NNP - 1 and alpha - internexin genes identified by autologous antibody screening of a pediatric neuroblastoma
  • Golbeck A, et al. 2002 Novel products of the HUD, HUC, NNP - 1 and alpha - internexin genes identified by autologous antibody screening of a pediatric neuroblastoma
  • Golbeck A, et al. 2002 Novel products of the HUD, HUC, NNP - 1 and alpha - internexin genes identified by autologous antibody screening of a pediatric neuroblastoma
  • for TDP - 43 or tau with a proportion of the inclusions also containing a - internexin in a further subgroup known as neuronal intermediate filament inclusion
  • Keratin, Cytokeratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins: