ⓘ Gamma-synuclein

                                     

ⓘ Gamma-synuclein

Gamma-synuclein is a protein that in humans is encoded by the SNCG gene.

Synuclein-gamma is a member of a family of synuclein proteins, which are thought to be involved in the pathogenesis of neurodegenerative diseases. A high level of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and tumour development of breast cancer. Gamma synuclein is synuclein protein that is found predominantly in the peripheral nervous system and the retina of the eye. It is also found in the brain, ovarian tumors, and in the olfactory epithelium. Gamma synuclein is the least conservative proteins synuclein.

Gamma-Synucleins expression in breast tumors is a marker of tumor progression as gamma synuclein in mammalian cells was first identified as breast cancer 1 gene BCSG1. Changes in the expression of gamma-synuclein observed in the retina of patients with Alzheimers disease. Normal cellular function of gamma-ray synuclein remains unknown.