ⓘ Lipoprotein lipase

                                     

ⓘ Lipoprotein lipase

Lipoprotein lipase is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins, into two free fatty acids and one monoacylglycerol molecule. It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. LPL requires ApoC-II as a cofactor.

LPL is attached to the luminal surface of endothelial cells in capillaries for protein glycosylphosphatidylinositol HDL-binding protein 1 GPIHBP1 and heparan sulfated peptidoglycan. It is most widely distributed in adipose, heart and skeletal muscle as well as in lactating mammary glands.

                                     
  • Lipoprotein lipase deficiency is a genetic disorder in which a person has a defective gene for lipoprotein lipase which leads to very high triglycerides
  • functions of hepatic lipase is to convert intermediate - density lipoprotein IDL to low - density lipoprotein LDL Hepatic lipase thus plays an important
  • pancreatic, hepatic and gastric lingual. These lipases are closely related to each other and to lipoprotein lipase EC 3.1.1.34 which hydrolyses triglycerides
  • including hepatic lipase endothelial lipase and lipoprotein lipase Not all of these lipases function in the gut see table Other lipases include LIPH
  • considered mature. Via apolipoprotein C - II, mature chylomicrons activate lipoprotein lipase LPL an enzyme on endothelial cells lining the blood vessels. LPL
  • the enzyme lipoprotein lipase and the VLDL returns to the circulation as a smaller particle with a new name, intermediate - density lipoprotein IDL The
  • lipoprotein lipase LPL in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides. Monoacylglycerol lipase is
  • high - density lipoprotein HDL At this point, nascent VLDL becomes a mature VLDL. Once in circulation, VLDL will come in contact with lipoprotein lipase LPL
  • into triglyceride - rich lipoproteins called chylomicrons. The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase LPL along the luminal
  • apolipoprotein very - low - density lipoprotein II: disulphide - bond - mediated dimerization is not essential for inhibition of lipoprotein lipase Biochem. J. 317 2