ⓘ 5α-Reductase

                                     

ⓘ 5α-Reductase

5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism. There are three isoenzymes of 5α-reductase, SRD5A1, SRD5A2, and SRD5A3, which vary in different tissues with age.

5α-reductase catalyze the following chemical reaction:

a 3-oxo-5α-steroid + acceptor ⇌ a 3-oxo-Δ 4 -steroid + reduced acceptor

Thus, the two substrates of these enzymes are 3-oxo-5α-steroids and acceptor, whereas its two products are 3-oxo-Δ4-steroid and a reduced acceptor. For example:

dihydrotestosterone + NADP + ⇌ {\displaystyle \rightleftharpoons } testosterone + NADPH + H +
                                     
  • 5α - Reductase inhibitors 5 - ARIs also known as dihydrotestosterone DHT blockers, are a class of medications with antiandrogenic effects which are used
  • 5α - Reductase deficiency is an autosomal recessive intersex condition caused by a mutation of the 5α - reductase type II gene. Individuals with 5 - ARD are
  • 3 - oxo - 5α - steroid 4 - dehydrogenase 2 is an enzyme that in humans is encoded by the SRD 5 A2 gene. It is one of three forms of 5α - reductase Steroid 5α - reductase
  • 3 - oxo - 5α - steroid 4 - dehydrogenase 1 is an enzyme that in humans is encoded by the SRD 5 A1 gene. It is one of three forms of 5α - reductase Steroid 5α - reductase
  • discovery and development of 5α - reductase inhibitors 5 - ARIs also known as dihydrotestosterone DHT blockers. These are two types of 5 - ARIs, categorized as
  • actions of the enzyme 5α - reductase analogously to the formation of dihydrotestosterone DHT from testosterone. When testosterone is 5α - reduced into DHT
  • 5α - Dihydrocortisol 5α - DHF also known as hydrallostane or as allodihydrocortisol, is a metabolite of cortisol that is formed by 5α - reductase It is present
  • of normethandrone formed by 5α - reductase Analogously to nandrolone and its 5α - reduced metabolite 5α - dihydronandrolone, 5α - DHNMT shows reduced affinity
  • DHT, 5α - dihydrotestosterone, 5α - DHT, androstanolone or stanolone is an endogenous androgen sex steroid and hormone. The enzyme 5α - reductase catalyzes