ⓘ ABCB11

                                     

ⓘ ABCB11

The product of the ABCB11 gene is an ABC transporter named BSEP Bile Salt Export Pump, or sPgp sister of P-glycoprotein. This membrane-associated protein is a member of the superfamily of ATP-binding cassette ABC transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies.

This protein is a member of the MDR / tap subfamily. Some members of the MDR / tap subfamily involved in multidrug resistance. This particular protein is responsible for the transport of taurocholate and other chocolate conjugates from hepatocytes of liver cells into bile. In humans the activity of this Transporter is an important determinant of bile and bile flow.

                                     
  • also known as P - glycoprotein ABCB 5 is a plasma membrane - spanning protein that in humans is encoded by the ABCB 5 gene. ABCB 5 is an ABC transporter and P - glycoprotein
  • resistance protein 3 is a protein that in humans is encoded by the ABCB 4 gene. ABCB 4 is associated with progressive familial intrahepatic cholestasis type
  • protein EhuC InterPro: IPR014342 ABCB 1 ABCB 10 ABCB11 ABCB 4 ABCB 5 ABCB 6 ABCB 7 ABCB 8 ABCB 9 ABCC1 ABCC10 ABCC 11 ABCC12 ABCC13 ABCC2 ABCC3 ABCC4
  • disease Type 2 OMIM 601847 also called ABCB11 deficiency or BSEP deficiency Type 3 OMIM 602347 also called ABCB 4 deficiency or MDR3 deficiency Type 4
  • B member 8, mitochondrial is a protein that in humans is encoded by the ABCB 8 gene. The membrane - associated protein encoded by this gene is a member of
  • ABCA5 ABCA6 ABCA7 ABCA8 ABCA9 ABCB 1 ABCB 10 ABCB11 ABCB 4 ABCB 5 ABCB 6 ABCB 7 ABCB 8 ABCB 9 ABCC1 ABCC10 ABCC 11 ABCC12 ABCC2 ABCC3 ABCC4 ABCC5
  • to inhibit the bile salt export pump BSEP ABCB11 and high levels of progesterone to inhibit the ABCB 4 MDR3 phospholipid transporter. Consequently
  • resistance protein 1 MDR1 or ATP - binding cassette sub - family B member 1 ABCB 1 or cluster of differentiation 243 CD243 is an important protein of the
  • HCC cells, and we established that ABCB 6 encodes a new blood group system Langereis, Lan Targeted sequencing of ABCB 6 in 12 unrelated individuals of the
  • transport assay is the detection of the inhibition of taurocholate transport by ABCB11 BSEP Efflux transporter - expressing cells actively pump substrates out