ⓘ XRN1 (gene)

                                     

ⓘ XRN1 (gene)

This gene encodes a member of the 5-3 exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including transcription, translation, homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants.

                                     
  • Exoribonuclease 2 XRN 2 also known as Dhm 1 - like protein is an exoribonuclease enzyme that in humans is encoded by the XRN 2 gene The human gene encoding XRN 2 shares
  • seen in a metazoan. Yeast contains Rat 1 and Xrn1 exonuclease. The Rat 1 works just like the human type Xrn 2 and Xrn1 function in the cytoplasm is in the
  • Dcp 1 - Dcp2 complex which removes the 5 cap, allowing for the 5 to 3 exoribonuclease Xrn1 to degrade the transcript completely. The role of Dcp 1 - Dcp2
  • decapping activator Dcp 1 the helicase Dhh 1 the exonuclease Xrn1 nonsense mediated decay factors Upf 1 Upf2, and Upf3, the LSm complex, Pat 1 and various other
  • terminator is a section of nucleic acid sequence that marks the end of a gene or operon in genomic DNA during transcription. This sequence mediates transcriptional
  • enzyme DCP2. A host of proteins accompany it including UPF 1 UPF2, UPF3A, Dcp 1 Dhh 1 XRN1 and others. The decapping enzyme removes the 5 cap leading
  • of the 5 - UTR of CLB2 mRNA that allows for rapid 5 - to - 3 degradation by XRN1 an exoribonuclease enzyme. RNase P and RNAse MRP are ribonucleoprotein complexes
  • while the 3 fragment is degraded from its 5 end by 5 - 3 exoribonuclease 1 XRN1 Dissociation of the target mRNA strand from RISC after the cleavage allow
  • Biochemistry. 108 1 14 21. doi: 10.1002 jcb.22249. PMID 19562739. Newbury, S. Woollard, A. 2004 The 5 - 3 exoribonuclease xrn - 1 is essential for
  • decay is initiated by the removal of the 5 cap followed by degradation by XRN1 an exoribonuclease enzyme. The other pathway by which mRNA is degraded is