ⓘ Epiregulin

                                     

ⓘ Epiregulin

Epiregulin consists of 46 amino acid residues. Its secondary structure contains approximately 30 percent of β-sheet in the strand. Some of the residues form loops and turns due to the hydrogen bonding. The percentage of β-sheet in epiregulin depends on the domain and the secondary structures that they occupy. The polymeric molecules of epiregulin has the formula weight of 5280.1 g/mol with a polypeptideL, a polymer type.

Structural motifs in the majority of proteins have a standard connection in the β motive. This means that the polypeptide chain is not connecting or crossovers as much as this type of connection was not observed. Epiregulin is one of the proteins, which is a typical connection in all β motif. In addition, in the structure of epiregulin forms a chain in the motif of β, it also forms a β-hairpin structural motif. In the β-hairpin, when two adjacent antiparallel β-strands connected by a β-turn.

                                     
  • Expression of betacellulin, heparin - binding epidermal growth factor and epiregulin in human malignant fibrous histiocytoma Anticancer Research. 24 3b
  • factor HB - EGF transforming growth factor - α TGF - α Amphiregulin AR Epiregulin EPR Epigen Betacellulin BTC neuregulin - 1 NRG1 neuregulin - 2 NRG2
  • PMID 9334263. Komurasaki T, Toyoda H, Uchida D, Morimoto S Dec 1997 Epiregulin binds to epidermal growth factor receptor and ErbB - 4 and induces tyrosine
  • embryo implantation: increases endometrial integrin - α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua Reproductive
  • 2.7.10.1 Epidermal growth factor, amphiregulin, betacellulin, epigen, epiregulin HB - EGF, TGFa GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478
  • ErbB1 HER1 Agonists: Amphiregulin Betacellulin EGF urogastrone Epigen Epiregulin Heparin - binding EGF - like growth factor HB - EGF Murodermin Nepidermin
  • ErbB1 HER1 Agonists: Amphiregulin Betacellulin EGF urogastrone Epigen Epiregulin Heparin - binding EGF - like growth factor HB - EGF Murodermin Nepidermin
  • ErbB1 HER1 Agonists: Amphiregulin Betacellulin EGF urogastrone Epigen Epiregulin Heparin - binding EGF - like growth factor HB - EGF Murodermin Nepidermin
  • ErbB1 HER1 Agonists: Amphiregulin Betacellulin EGF urogastrone Epigen Epiregulin Heparin - binding EGF - like growth factor HB - EGF Murodermin Nepidermin