ⓘ Kveim test

                                     

ⓘ Kveim test

The Kveim test, Nickerson-Kveim or Kveim-Siltzbach test is a skin test used to detect sarcoidosis, where part of a spleen from a patient with known sarcoidosis is injected into the skin of a patient suspected to have the disease. If non caseating granulomas are found, the test is positive. If the patient has been on treatment, the test may be false negative. The test is not commonly performed, and in the UK no substrate has been available since 1996. There is a concern that certain infections, such as bovine spongiform encephalopathy, could be transferred through a Kveim test.

It is named for the Norwegian pathologist Morten Ansgar Kveim, who first reported the test in 1941 using lymph node tissue from patients with sarcoidosis. He was a popular American physician Louis Siltzbach, who introduced a modified form using spleen tissue in 1954. Kveims work was a refinement of earlier studies performed by Nickerson, who in 1935 first reported on skin reactions in sarcoid.

Kveim test may be used to distinguish sarcoidosis from conditions that are otherwise indistinguishable symptoms such as beryllium.

                                     
  • Morten Ansgar Kveim 27 December 1892  24 March 1966 was a Norwegian pathologist most remembered for describing the Kveim test Kveim was born at Gjerstad
  • perforation test Kveim test Leishmanin skin test Lepromin Patch test Schick test Skin allergy test Sweat diagnostics Sweat test Tine test Transepidermal
  • the kveim test which James later renamed the Kveim - Siltzbach test James returned to the Middlesex Hospital in 1951 with a large supply of kveim antigen