ⓘ Asparagine synthetase
Asparagine synthetase is a chiefly cytoplasmic enzyme that generates asparagine from aspartate. This amidation reaction is similar to that promoted by glutamine synthetase. The enzyme is ubiquitous in its distribution in mammalian organs, but basal expression is relatively low in tissues other than the exocrine pancreas.
Above-average presence of asparagine synthetase in certain strains of leukemia was associated with a significant factor of resistance to chemotherapy, particularly chemotherapy, L-Asparaginase.
- Asparagine synthase glutamine - hydrolysing EC 220.127.116.11, asparagine synthetase glutamine - hydrolysing glutamine - dependent asparagine synthetase asparagine
- enzyme asparagine synthetase produces asparagine AMP, glutamate, and pyrophosphate from aspartate, glutamine, and ATP. In the asparagine synthetase reaction
- asparaginyl transfer RNA synthetase asparaginyl transfer ribonucleic acid synthetase asparagyl - transfer RNA synthetase and asparagine translase. This enzyme
- ADP - forming Other names in common use include asparagine synthetase ADP - forming and asparagine synthetase adenosine diphosphate - forming This enzyme
- AMP - forming Other names in common use include asparagine synthetase and L - asparagine synthetase This enzyme participates in 3 metabolic pathways:
- alanine, asparagine aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class - II synthetases DARS DARS2
- alanine, asparagine aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class - II synthetases Glutamyl - tRNA
- biosynthesis of asparagine originates with aspartate using a transaminase enzyme. The enzyme asparagine synthetase produces asparagine AMP, glutamate
- also called nondiscriminating asparaginyl - tRNA synthetase This enzyme participates in alanine and asparagine metabolism. Ibba M, Soll D 2000 Aminoacyl - tRNA
- Homan ER August 1976 DON, CONV and DONV - II. Inhibition of L - asparagine synthetase in vivo Biochem. Pharmacol. 25 16 1851 8. doi: 10.1016 0006 - 2952 76 90189 - 1
- Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding
- glutamate and oxaloacetate. Asparagine is synthesized by an ATP - dependent addition of an amino group onto aspartate asparagine synthetase catalyzes the addition
- Coruzzi. 1990 Dark - induced and organ - specific expression of two asparagine synthetase genes in Pisum sativum. EMBO J. 9: 323 - 32. Gutierrez, R., et al