ⓘ Deoxycytidine kinase

                                     

ⓘ Deoxycytidine kinase

Deoxycytidine kinase is an enzyme which is encoded by the DCK gene in humans. dCK predominantly phosphorylates deoxycytidine and converts dC into deoxycytidine monophosphate. dCK catalyzes one of the initial steps in the nucleoside salvage pathway and has the potential to phosphorylate other preformed nucleosides, specifically deoxyadenosine and deoxyguanosine, and convert them into their monophosphate forms. There has been recent biomedical research interest in investigating dCKs potential as a therapeutic target for different types of cancer.

                                     
  • ribonucleoside cytidine, but with one hydroxyl group removed from the 2 position. Deoxycytidine can be phosphorylated by deoxycytidine kinase DCK
  • deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine and deoxyuridine. The encoded enzyme localizes to the mitochondria
  • d CMP kinase EC 2.7.4.25, prokaryotic cytidylate kinase deoxycytidylate kinase dCMP kinase deoxycytidine monophosphokinase is an enzyme with systematic
  • name Death Cube K Deschloroketamine, a dissociative anesthetic drug Deoxycytidine kinase an enzyme DHA City, Karachi, a planned city in Karachi, Pakistan
  • predominantly by two deoxyribonucleoside kinases cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase The protein encoded by this gene is
  • via hENT1, hENT2, and hCNT2, where upon it is phosphorylated by deoxycytidine kinase to generate clofarabine - 5 - monophosphate. The rate - limiting step
  • deoxycytidylate kinase deoxycytidylate kinase CMP kinase CTP: CMP phosphotransferase, dCMP kinase deoxycytidine monophosphokinase, UMP - CMP kinase ATP: UMP - CMP
  • which nucleoside diphosphate kinase can phosphorylate into thymidine triphosphate. The nucleosides cytidine and deoxycytidine can be salvaged along the uracil
  • Johansson M, Karlsson A 1999 Phosphorylation of deoxycytidine analog monophosphates by UMP - CMP kinase molecular characterization of the human enzyme
  • B, Calvo BD, Adema AD, Peters GJ December 2011 Regulation of deoxycytidine kinase expression and sensitivity to gemcitabine by micro - RNA 330 and promoter