ⓘ RAMP1

                                     

ⓘ RAMP1

Receptor activity modifying protein 1 is a protein that in humans is encoded by the RAMP1 gene.

The protein encoded by this gene is a member of the ramp family of single transmembrane domain protein called the calcitonin receptor activity protein modifications ramps. Ramps are type I transmembrane protein with a N terminal extracellular and cytoplasmic with Terminus. Ramps are required to transport calcitonin-receptor-like receptor CALCRL to the plasma membrane. CALCRL, a receptor with seven transmembrane domains, can function as a calcitonin gene-related peptide CGRP receptor or adrenomedullin receptor, depending on the family members expressed the ramp. In combination with Lin ISM 1 protein, CALCRL functions as a receptor for CGRP. Lin 1 Rev protein is involved in the terminal glycosylation, maturation and presentation of the CGRP receptor at the cell surface. Lin ISM 1 protein can also interact with the calcitonin CT receptor protein heteromerisation of Lin ISM 1 TT CT converts from a calcitonin receptor with receptor Amelina Amy 1

                                     
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