ⓘ Mannose 6-phosphate receptor

                                     

ⓘ Mannose 6-phosphate receptor

The mannose 6-phosphate receptors are transmembrane glycoproteins that target enzymes to lysosomes in vertebrates.

Mannose-6-phosphate receptors bind newly synthesized lysosomal hydrolases in the TRANS-Golgi network TGN and deliver them to pre-lysosomal compartments. There are two different Mprs, one of ~300кда and less demersum receptor ~46kDa. Large receptor is called the cation-independent mannose-6-phosphate receptor CI-MPR, while the smaller receptor CD-MPR requires divalent cations to efficiently recognize lysosomal hydrolases. While divalent cations are not required for binding ligands of the human CD-MPR, the item was retained.

Both of these receptors bind to terminal mannose 6-phosphate with similar affinity for CI-MPR = 7 µm, the CD-MPR = 8 µm and have similar signals in their cytoplasmic domain for intracellular people.