ⓘ TRIF

                                     

ⓘ TRIF

TIR-domain-containing adapter-inducing interferon-β is an adapter in responding to activation of toll-like receptors. It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter.

Toll-like receptors tlrs system recognize the individual components of microbial invaders and activate an immune response to such pathogens. After these receptors recognize highly pathogenic conservation models, the downward signal cascade is activated in order to stimulate the release of proinflammatory cytokines and chemokines, and upregulate the expression of immune cells. All systems of tlrs is the TIR domain that initiates the signaling cascade through TIR adapters. Adapters are platforms that organize downstream signaling cascades leading to a specific cellular response after exposure to this pathogen.

                                     
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  • PMID 17372010. Rowe DC, McGettrick AF, Latz E, et al. 2006 The myristoylation of TRIF - related adaptor molecule is essential for Toll - like receptor 4 signal transduction
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  • TRIM38 negatively regulates TLR3 - mediated IFN - β signaling by targeting TRIF for degradation PLoS ONE. 7 10 e46825. doi: 10.1371 journal.pone.0046825
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