ⓘ Idiotype

                                     

ⓘ Idiotype

In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T-cell receptor molecules based upon the antigen binding specificity and therefore structure of their variable region. The variable region of antigen receptors of T cells and B cells contain complementarity-determining regions with unique amino acid sequences. They define the surface and properties of the variable region, determining the antigen specificity and therefore the idio tope of the molecule. Immunoglobulins or TCRs with a shared idiotope are the same idio type. Antibody idiotype is determined by:

  • Somatic hypermutations. (Соматических гипермутаций)
  • Gene rearrangement. (Перегруппировка генов)
  • Junctional diversity. (Узловой разнообразия)
  • N-nucleotides. (Н-нуклеотидов)
  • P-nucleotides palindromic nucleotides at sites of single-strand breaks.
                                     
  • receptors. Idiotopes are aggregated into idiotypes specific of their target antigen. An example of anti - idiotype antibody is Racotumomab. In one example
  • immunoglobulin idiotype or Id Id - secreting clones are identified by a bioinformatics approach which confirms a match of each vaccine s unique idiotype sequence
  • multiple idiotopes and the set of these individual idiotopes is termed the idiotype of the antibody. Idiotopes contrast with allotopes, which are non - varying
  • Abagovomab is a mouse anti - idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen CA - 125 highly expressed in the epithelial ovarian
  • can be used in resolving paternity disputes. Allotype disambiguation Idiotype Isotype THE STRUCTURE AND FUNCTION OF IMMUNOGLOBULINS - ANTIBODIES Retrieved
  • antibody against cytomegalovirus. Third communication: correspondence of the idiotype activity and virus neutralization activity of the new monoclonal antibody
  • antibody - secreting cell to form a heterohybridoma. This cell then secretes the unique idiotype or immunoglobulin antigen characteristic of the individual tumor, which
  • antibody commonly found on a B leukocyte. The engraved inner portions of idiotype encircled region no.5 in the above diagram is the paratope where the
  • idiotype and activate CD4 T cells. Proc Natl Acad Sci U S A. Mar 14 97 6 2697 - 702. PMID 10706628 Fredriksen AB, Bogen B. 2007 Chemokine - idiotype
  • lead scientific advisor for a new biotech company specializing in anti - idiotypes a novel vaccine technology, Salk called the proposal liberating.