ⓘ CYP3A7

                                     

ⓘ CYP3A7

CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults. The gene location is 7q22.1.

Group СУР3А enzymes are the most abundantly expressed members of the family of cytochrome P450 in the liver. They are responsible for the metabolism of more than 50% of all clinical drugs.

                                     
  • The CYP 3 A cluster consists of four genes: CYP 3 A4, CYP 3 A5, CYP3A7 and CYP 3 A43. The region also contains four pseudogenes: CYP 3 A51P, CYP 3 A52P, CYP 3 A54P
  • that CYP 3 A5 is expressed as a 52.5 - kD protein, whereas CYP 3 A4 migrates as a 52.0 - kD protein. The human CYP 3 A subfamily, CYP 3 A4, CYP 3 A5, CYP3A7 and CYP 3 A43
  • CYP 2A 7 cytochrome P450, family 2, subfamily A, polypeptide 7 is a protein that in humans is encoded by the CYP 2A 7 gene. This gene encodes a member of
  • 7 - hydroxycoumarin, is used as a probe for CYP 2A6 activity. The CYP 2A6 gene is part of a large cluster of cytochrome P450 genes from the CYP 2A, CYP 2B
  • Cytochrome P450 2D6 CYP 2D6 is an enzyme that in humans is encoded by the CYP 2D6 gene. CYP 2D6 is primarily expressed in the liver. It is also highly expressed
  • Cytochrome P450 3 A43 is a protein that in humans is encoded by the CYP 3 A43 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes
  • 25 - hydroxycholesterol 7 - alpha - hydroxylase also known as oxysterol and steroid 7 - alpha - hydroxylase is an enzyme that in humans is encoded by the CYP 7 B1 gene. This
  • Cytochromes P450 CYPs are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize
  • 7 alpha - hydroxylase also known as cholesterol 7 - alpha - monooxygenase or cytochrome P450 7 A1 CYP 7 A1 is an enzyme that in humans is encoded by the CYP 7A1
  • Cytochrome P450 2C9 abbreviated CYP 2C9 is an enzyme that in humans is encoded by the CYP 2C9 gene. CYP 2C9 is an important cytochrome P450 enzyme with
  • enzyme that in humans is encoded by the CYP 4F 3 gene. CYP 4F 3 encodes two distinct enzymes, CYP 4F 3 A and CYP 4F 3 B, which originate from the alternative splicing