ⓘ GAK (protein)

                                     

ⓘ GAK (protein)

In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases CDKs, whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the cyclin box. In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5.

Cyclin g-associated kinase got its name because it is immunoprecipitated with a cyclin g, but now it doesnt seem to be associated with him. Cyclin g-associated kinase is homologous in function auxilin, a protein which, when in conjunction with Hsc70 uncoats clathrin in neuronal cells. However, the location of the cyclin g-associated kinase is not in the brain, and near the TRANS-Golgi network of non-neuronal cells such as those found in the liver and testes. The SJC also known to be associated with focal adhesions, although the exact ratio between two unknowns.

                                     
  • Korean military officer Gak South Sudan Ağdam, Khojavend, Azerbaijan GAK EP a 1994 recording by Richard D. James GAK protein a kinase Gamkonora language
  • The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. Protein kinases are a group
  • The endoplasmic reticulum membrane protein complex EMC is a putative endoplasmic reticulum - resident membrane protein co - chaperone. The EMC is evolutionarily
  • Structure. 3 11 1225 33. doi: 10.1016 s0969 - 2126 01 00258 - 1. PMID 8591033. Gak ER, Tsygankov YD, Chistoserdov AY June 1997 Organization of methylamine
  • Chp1 Cysteine string protein CSP Cyp40 Djp1 DnaJ E3 E4 - ubiquitin ligase FKBP52 GAK GroES GrpE Hch1 Hip Hsc70 - interacting protein ST13 Hop Hsp70 Hsp90
  • PMID 11573956. Korolchuk VI, Banting G Jun 2002 CK2 and GAK auxilin2 are major protein kinases in clathrin - coated vesicles Traffic. 3 6 428 39
  • phospho - tyrosine binding domain, and GAK whose inactive phosphatase domain instead binds phospholipds. Kinase Kinome Phosphatase Protein phosphatase Mark J. Chen
  • Cyclin - G1 is a protein that in humans is encoded by the CCNG1 gene. The eukaryotic cell cycle is governed by cyclin - dependent protein kinases CDKs whose
  • Tumor protein D54 is a protein that in humans is encoded by the TPD52L2 gene. Model organisms have been used in the study of TPD52L2 function. A conditional
  • doi: 10.1161 01.RES.0000081980.63146.69. PMID 12805243. Koronyo - Hamaoui M, Gak E, Stein D, Frisch A, Danziger Y, Leor S, Michaelovsky E, Laufer N, Carel
  • Naito Y, Uchihashi T, Kato Y, Mukai S, Yabuta N, Nojima H March 2017 GAK is phosphorylated by c - Src and translocated from the centrosome to chromatin