ⓘ Immunotoxin

                                     

ⓘ Immunotoxin

An immunotoxin is an artificial protein consisting of a targeting portion linked to a toxin. When the protein binds to that cell, it is taken in through endocytosis, and the toxin kills the cell. They are used for the treatment of some kinds of cancer and a few viral infections.

                                     
  • An anti - CD22 immunotoxin is a monoclonal antibody targeting CD22 linked to a cytotoxic agent. They are being studied in the treatment of some types
  • The Recombinant Immunotoxin Collaborative Group RICG is a group of scientists specialising in immunology, biochemistry and molecular biology from the
  • Anti - CD19 immunotoxin is a monoclonal antibody linked to a toxic substance. It is being studied in the treatment of some types of B - cell cancer. Anti - CD19
  • Resimmune or A - dmDT390 - bisFv UCHT1 is an experimental drug - an anti - T cell immunotoxin - that is being investigated for treatment of T cell blood cancers such
  • Health He is currently co - chief of the LMB and is working on various Immunotoxin Therapies. Pastan pioneered the field of receptor biology in animal cells
  • Moxetumomab pasudotox is an anti - CD22 immunotoxin designed for the treatment of cancer. Moxetumomab pasudotox is currently being developed by the biologics
  • also involved in the B cell trafficking to Peyer s patches in mice. An immunotoxin BL22, that targets this receptor is being tested at the NIH. As a treatment
  • radioisotope see radioimmunotherapy. When the conjugates include a toxin see immunotoxin Goldenberg DM, Sharkey RM 2007 Novel radiolabeled antibody conjugates
  • diphtheria toxin have also been used, again with variations in success. Immunotoxins consisting of a monoclonal antibody linked to saporin have been developed