ⓘ Sulfonylurea receptor

                                     

ⓘ Sulfonylurea receptor

In molecular biology, the sulfonylurea receptors are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels K ir 6.x. The association of four K ir 6.x and four SUR subunits form an ion conducting channel commonly referred to as the K ATP channel.

There are three forms of the receptor sulfonylureas are, SUR1, encoded by ABCC8 gene and SUR2A and SUR2B which are splice variants arising from a single ABCC9 gene.

                                     
  • channel Kir6.x and sulfonylurea receptor SUR which associate with a stoichiometry of 4: 4. Furthermore, it has been shown that sulfonylureas interact with the
  • have not been fully described. ATP - binding cassette transporter Sulfonylurea receptor GRCh38: Ensembl release 89: ENSG00000006071 - Ensembl, May 2017
  • ATP - binding cassette, sub - family C member 9 ABCC9 also known as sulfonylurea receptor 2 SUR2 is an ATP - binding cassette transporter that in humans is
  • SUR2 may refer to: Sulfonylurea receptor Sphinganine C4 - monooxygenase
  • Control of insulin secretion by sulfonylureas meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets Biochemical
  • Sur SC, a sports club based in Sur, Oman Sulfonylurea receptor or SUR, the molecular target of sulfonylurea antidiabetic drugs Sydney University Regiment
  • ATP - sensitive potassium channels KATP inhibitory regulatory subunit sulfonylurea receptor 1 SUR1 in pancreatic beta cells. This inhibition causes cell membrane
  • family. This protein was identified as an endogenous ligand for the sulfonylurea receptor ABCC8 SUR1. ABCC8 is the regulatory subunit of the ATP - sensitive
  • the ABCC9 gene. ABCC9 gene provides a blueprint for creating the sulfonylurea receptor 2 in the human body. The gene is located on short arm of chromosome
  • cell, is controlled by G - proteins and is found associated with the sulfonylurea receptor SUR to constitute the ATP - sensitive K channel. Mutations in this