ⓘ Osteoprotegerin

                                     

ⓘ Osteoprotegerin

Osteoprotegerin, also known as osteoclastogenesis inhibitory factor or tumour necrosis factor receptor superfamily member 11B, is a cytokine receptor of the tumour necrosis factor receptor superfamily encoded by the TNFRSF11B gene.

OPG was first discovered in the novel stands out TNFR-related protein, which plays a role in regulation of bone density, and later for its role as a decoy receptor activator of nuclear factor Kappa-B ligand and soluble forms. OPG also binds with TNF-related apoptosis-inducing ligand Trail and inhibits trail induced apoptosis of specific cells, including tumor cells. Other ligands of OPG include syndecan-1, glycosaminoglycans, the von Willebrand factor and factor VIII-von Willebrand factor complex.

OPG was identified as having an important role in tumor growth and metastasis, heart disease, immune system development and signaling, mental health, diabetes and prevention of pre-eclampsia and osteoporosis during pregnancy.

                                     
  • node development, thermal regulation, and mammary gland development. Osteoprotegerin OPG is a decoy receptor for RANK, and regulates the stimulation of
  • OPG may refer to: Osteoprotegerin Office of the Public Guardian disambiguation Office of HM Paymaster General Oldroyd Publishing Group Online Policy
  • periodontal ligament undifferentiated mesenchymal cells. EMD also stimulates osteoprotegerin serving to trigger osteoblasts and indirectly inhibit both osteoclastogenesis
  • member 11 TNFSF11 TNF - related activation - induced cytokine TRANCE osteoprotegerin ligand OPGL and osteoclast differentiation factor ODF is a protein
  • Fujikawa Y, Sabokbar A, Athanasou NA. 2000 The effect of osteoprotegerin and osteoprotegerin ligand on human arthroplasty macrophage - osteoclast differentiation
  • ligand RANKL also called osteoclast differentiation factor ODF and osteoprotegerin ligand OPGL is a regulator of osteoclast function. In physiological
  • Wood, D. J., Zheng, M. H. 2000 Gene Expression of Osteoprotegerin Ligand, Osteoprotegerin and REceptor Activator of NF - kB in Giant Cell Tumor of
  • to be RANKL dependent. Osteoclast differentiation is inhibited by osteoprotegerin OPG which is produced by osteoblasts and binds to RANKL thereby
  • increased levels in patients at risk for cardiovascular disease. Also osteoprotegerin which involved with regulation of a key inflammatory transcription