ⓘ Minor histocompatibility antigen
Minor histocompatibility antigen are receptors on the cellular surface of donated organs that are known to give an immunological response in some organ transplants. They cause problems of rejection less frequently than those of the major histocompatibility complex. Minor histocompatibility antigens are diverse, short segments of proteins and are referred to as peptides. These peptides are normally around 9-12 amino acids in length and are bound to both the major histocompatibility complex class I and class II proteins. Peptide sequences can differ among individuals and these differences arise from SNPs in the coding region of genes, gene deletions, frameshift mutations, or insertions. About a third of the characterized MiHAs come from the Y chromosome. The proteins are composed of a single immunogenic HLA allele. Prior to becoming a short peptide sequence, the proteins expressed by these polymorphic or diverse genes need to be digested in the proteasome into shorter peptides. These endogenous or self peptides are then transported into the endoplasmic reticulum with a peptide transporter pump called TAP where they encounter and bind to the MHC class I molecule. This contrasts with MHC class II moleculess antigens which are peptides derived from phagocytosis/endocytosis and molecular degradation of non-self entities proteins, usually by antigen-presenting cells. MiHA antigens are either ubiquitously expressed in most tissue like skin and intestines or restrictively expressed in the immune cells.
Minor histocompatibility antigens are the result of normal proteins, which themselves are polymorphic in a given population. Even when the transplant donor and recipient are identical with respect to their major histocompatibility complex genes, amino acid differences in minor proteins can cause the grafted tissue is rejected slowly. Some of the identified consequence and Y-chromosome encoded Mihas
- HMHA1 histocompatibility minor HA - 1 van Lochem E, van der Keur M, Mommaas AM, et al. 1997 Functional expression of minor histocompatibility antigens
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- large number of parasite antigens Antigen - presenting cells present antigens in the form of peptides on histocompatibility molecules. The T cell selectively
- O, Buus S, Vindelov L October 2010 Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative
- STT3B gene. The STT3B protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6 dom1 Like ITM1 MIM 601134
- finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a
- professor of transplantation biology, especially regarding minor histocompatibility antigen at Leiden University. Goulmy is an expert in the area of tissue
- phenotype see Hh antigen system Histocompatibility antigen a major factor in graft rejection. Even when Major Histocompatibility Complex genotype is
- involved in protein protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts.
- The human leukocyte antigen HLA system or complex is a gene complex encoding the major histocompatibility complex MHC proteins in humans. These cell - surface