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UBE2E1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiqui ...

UCN2

Urocortin-2 is a protein that in humans is encoded by the UCN2 gene. This gene is a member of the sauvagine / corticotropin-releasing factor / urotensin I family. It is structurally related to the corticotropin-releasing factor CRF gene and the e ...

UPK1B

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These prote ...

UQCRC1

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene. Its gene product is a subunit of the respiratory chain protein Ubiquinol-Cytochrome C reductase UQCR, complex III or cytochrome BC1 comple ...

Uridine monophosphate synthetase

Uridine monophosphate synthase is the enzyme that catalyses the formation of uridine monophosphate, an energy-carrying molecule in many important biosynthetic pathways. In humans, the gene that codes for this enzyme is located on the long arm of ...

USP4

Ubiquitin specific protease 4 is an enzyme that cleaves ubiquitin from a number of protein substrates. Prior to the standardization of nomenclature USP4 was known as UNP, and was one of the first deubiquitinating enzymes to be identified in mamma ...

WDR6

WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conservative regions of approximately 40 amino acids, usually enclosed in ...

WNT5A

The WNT gene family consists of structurally related genes that encode secreted signaling lipid modified glycoproteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate a ...

WNT7A

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during ...

WWTR1

WWTR1 It is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The ...

XRN1 (gene)

This gene encodes a member of the 5-3 exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, ...

ZIC1

ZIC1 is a member of the Zi nc finger of the c erebellum protein family. ZIC1 is classified as ZEKE protein by maintaining five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. ZIC1 is located in close genomic config ...

Zinc finger protein 197

This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Krupp ...

Zinc finger protein 717

This gene encodes a Kruppel-associated box KRAB zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell ...

3-hydroxyacyl-CoA dehydrogenase

In enzymology, a 3-hydroxyacyl-CoA dehydrogenase is an enzyme that catalyzes the chemical reaction S-3-hydroxyacyl-CoA + NAD + ⇌ {\displaystyle \rightleftharpoons } 3-oxoacyl-CoA + NADH + H + Thus, the two substrates of this enzyme are S-3-hydrox ...

ABCG2

ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338.

ABHD18

ABHD18 is found on the positive strand of the human genome at 4q28.2. It is 74.4 kbp. The gene contains 17 exons. The longest mRNA transcript is composed of 13 exons and is 2200 base pairs.

ADAMTS3

A disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene. The protein encoded by this gene is the major procollagen II N-propeptidase.

ADD1

Alpha-adducin is a protein that in humans is encoded by the ADD1 gene. Adducins are a family of cytoskeleton proteins encoded by three genes. Adducin is a heterodimeric protein that consists of related subunits, which are made from certain genes, ...

ADH1A

Alcohol dehydrogenase 1A is an enzyme that in humans is encoded by the ADH1A gene. This gene encodes class I alcohol dehydrogenase, alpha subunit that is a member of a family of dehydrogenases of alcohol. The members of this family of enzyme meta ...

ADH1B

Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene. The protein encoded by this gene is a member of a family of dehydrogenases of alcohol. The members of this family of enzyme metaboliziruet various substrates, incl ...

ADH4

Alcohol dehydrogenase 4 is an enzyme that in humans is encoded by the ADH4 gene. This gene encodes class II alcohol dehydrogenase 4 Pi subunit, which is a member of a family of dehydrogenases of alcohol. The members of this family of enzyme metab ...

ADH6

Alcohol dehydrogenase 6 is an enzyme that in humans is encoded by the ADH6 gene. This gene encodes class V alcohol dehydrogenase, which is a member of a family of dehydrogenases of alcohol. The members of this family metaboliziruet various substr ...

ADH7

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, h ...

ADP/ATP translocase 4

ADP/ATP translocase 4 is an enzyme that in humans is encoded by the SLC25A31 gene on chromosome 4. This enzyme inhibits apoptosis by catalyzing ADP/ATP exchange across the mitochondrial membranes and regulating membrane potential. In particular, ...

Afamin

This gene is a member of the albumin gene family, which comprises four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally related serum transport proteins that are known to be evolutionarily related. ...

AFAP1

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene. The protein encoded by this gene is a SRC binding partner. He could be a potential modulator of actin filament integrity in response to cellular signals ...

AGPAT9

Glycerol-3-phosphate acyltransferase 3 is an enzyme that in humans is encoded by the AGPAT9 gene. GPAT-3 is also known as: Lysophosphatidic acid acyltransferase theta LPAAT-theta, or. 1-acylglycerol-3-phosphate O-acyltransferase 9 AGPAT9. Lung ca ...

Alpha-2C adrenergic receptor

The alpha-2C adrenergic receptor, also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.

Alpha-Mannosidase

alpha-Mannosidase is an enzyme involved in the cleavage of the alpha form of mannose. Its systematic name is alpha-D-mannoside mannohydrolase.

ALPK1

Alpha-protein kinase 1 is an enzyme that in humans is encoded by the ALPK1 gene. In contrast to most eukaryotic protein kinases, alpha kinases, such as Lak, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical c ...

Amidophosphoribosyltransferase

Amidophosphoribosyltransferase, also known as glutamine phosphoribosylpyrophosphate amidotransferase, is an enzyme responsible for catalyzing the conversion of 5-phosphoribosyl-1-pyrophosphate into 5-phosphoribosyl-1-amine, using the amine group ...

Aminoadipate-semialdehyde dehydrogenase

This gene encodes a member of the non-ribosome peptide syntesase NRPS enzyme family. The encoded protein contains an AMP-binding domain, PP-binding phosphopantetheine, or pantetheine 4phosphate-binding domain and the Pyrrolo-quinoline quinon PQQ ...

ANAPC4

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene. A large protein complex called the anaphase-promoting complex APC, or cyclosome, promotes metaphase-anaphase transition in ubiquitinating its specific ...

ANKRD17

Ankyrin repeat domain-containing protein 17 is a protein that in humans is encoded by the ANKRD17 gene. This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies in mice suggest that this pr ...

Annexin A3

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene. This is abnormally expressed in fetuses as IVF and ICSI, which may contribute to the increased risk of birth defects in these areas of art. This gene encodes a member of the ann ...

Annexin A5

Annexin A5 is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membr ...

ANP32C

Phosphoprotein 32 PP32 is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and ar ...

APBB2

Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene. The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta-protein precursor of beta-amyloid precur ...

ASAHL

N-acylethanolamine-hydrolyzing acid amidase is an enzyme that in humans is encoded by the NAAA gene. This gene encodes an N-acylethanolamine-gidrolizuemye enzyme, which is highly similar to acid ceramidase. Several variants of transcripts encodin ...

Aspartylglucosaminidase

N--L-asparaginase is an enzyme that in humans is encoded by the AGA gene. Aspartylglucosaminidase is an amidohydrolase enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamine ...

ATP5I

ATP synthase subunit e, mitochondrial is an enzyme that in humans is encoded by the ATP5ME gene. Mitochondrial ATP synthase catalyzes ATP synthesis using the electrochemical gradient of protons across the inner membrane in oxidative phosphorylati ...

B cell scaffold protein with ankyrin repeats 1

The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1.4.5 ...

Bank1

Bank1 is a protein-encoding human gene located on chromosome 4 (4q24. Adaptor protein that binds the proteins of the family SCR with Calcium channels in the LB.

BBS7

Bardet–Biedl syndrome 7 is a protein that in humans is encoded by the BBS7 gene. Mutations in this gene are associated with bardet–Biedl syndrome syndrome.

BBS12

Bardet–Biedl syndrome 12 is a protein that in humans is encoded by the BBS12 gene. Mutations in this gene are associated with bardet–Biedl syndrome syndrome.

Beta-glucosidase

Beta-glucosidase is an enzyme that catalyzes the hydrolysis of the glycosidic bonds to terminal non-reducing residues in beta-D-glucosides and oligosaccharides, with release of glucose. Synonyms, derivatives, and related enzymes include gentiobia ...

Beta-mannosidase

Beta-mannosidase is an enzyme with systematic name beta-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene. This enzyme catalyses the following chemical reaction Hydrolysis of terminal, non-reducing beta-D-mannose residues i ...

BMP2K

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins BMPs play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene pro ...

C4orf51

The C4orf51 gene is located at 4q31.21 on the plus strand of chromosome 4. The gene spans 120.289 base pairs and contains 6 exons. The genomic neighborhood of C4orf51 includes LOC285422, LINC02491, NCOA4P3, and MMAA, all located upstream of C4orf ...