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MPHOSPH10

U3 small nucleolar ribonucleoprotein protein MPP10 is a protein that in humans is encoded by the MPHOSPH10 gene. This gene encodes a protein that fosfauriliruetsa during mitosis. The protein is localized in the nucleolus during interphase, and th ...

MPV17

Protein MPV17 is a protein that in humans is encoded by the MPV17 gene. It is a mitochondrial inner membrane protein, which has a so far largely unknown role in mtDNA maintenance. Protein MPV17 is expressed in human pancreas, kidney, muscle, live ...

MRPS9

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes mitoribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 7 ...

MSH2

DNA mismatch repair protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for ...

MTHFD2

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial is an enzyme that in humans is encoded by the MTHFD2 gene. This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme methylenetetrahydrofolate dehydrog ...

MTIF2

Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene. During the initiation of protein biosynthesis, initiation factor 2 if-2 promotes binding of the initiator tRNA to the small subunit of the ...

MXD1

MAD protein is a protein that in humans is encoded by the MXD1 gene. MAD-Max dimerization protein belongs to a subfamily of Max-interacting proteins. This protein competes with BA for binding to max to form a sequence-specific DNA-binding complex ...

MYT1L

This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger ...

NABP1

Single-stranded DNA ssDNA-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage.

Natriuretic peptide precursor C

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene. The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide.

NDUFB3

NADH dehydrogenase 1 beta subcomplex, 3, 12kDa is a protein that in humans is encoded by the NDUFB3 gene. NADH dehydrogenase 1 beta subcomplex, 3, 12kDa is an accessory subunit of the NADH dehydrogenase complex, located in the mitochondrial inner ...

Neuromedin S

Neuromedin is a 36-amino acid neuropeptide found in the brain of humans and other mammals. It is produced in the suprachiasmatic nucleus of the hypothalamus and is related to neuromedin U. It is thought to be involved in regulation of circadian r ...

Neuropilin 2

Neuropilin 2 is a protein that in humans is encoded by the NRP2 gene. This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {SEMA domain, immunoglobulin domain IG, shor ...

NLRC4

The NLRC4 protein is highly conserved across mammalian species. It bears homology to the C. elegans Ced4 protein. It contains an n-terminal CARD domain, a central nucleotide binding/NACHT domain, and a c-terminal leucine rich repeat LRR domain. I ...

Notochord homeobox (NOTO) gene

Homeobox protein notochord is a transcription factor encoded by the gene notochord homeobox located on the short arm of chromosome 2 in humans. An ortholog of NOTO is found in the house mouse, among other species, as the gene notochord homeobox l ...

NRXN1

Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene. Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of w ...

Nucleoporin 35

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is part of the nuclear pore complex NPC. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the ...

ODC1

Ornithine decarboxylase is an enzyme that in humans is encoded by the ODC1 gene. This gene encodes the rate-limiting enzyme of the metabolic pathway for synthesis of polyamines, which catalyzes ornithine to putrescine. The level of enzyme activit ...

OLA1

Obg-like ATPase 1 is an enzyme that in humans is encoded by the OLA1 gene. Ola1 belongs to the protein family of Obg-like GTPases but defines an exceptional example of a protein that has evolved altered nucleotide specificity and binds adenosine ...

OR6B2

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors GPCR arising fr ...

OR6B3

Olfactory receptor 6B3 is a protein that in humans is encoded by the OR6B3 gene. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. In the olfactory receptor pr ...

ORC2

The origin recognition complex ORC is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and ...

ORC4

The origin recognition complex ORC is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and ...

Ornithine decarboxylase

The enzyme ornithine decarboxylase catalyzes the decarboxylation of ornithine to form putrescine. This reaction is the committed step in polyamine synthesis. In humans, this protein has 461 amino acids and forms a homodimer.

Otoferlin

Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has three C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis fac ...

PAPOLG

Poly polymerase gamma is an enzyme that in humans is encoded by the PAPOLG gene. This gene encodes a member of the polya polymerase family which catalyzes template-independent extension of 3 ends of DNA / RNA Strands. This enzyme shares 60% ident ...

PCBP1

Poly-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene. This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues PCBP3 and PCBP4 w ...

PDE6D

Retinal rod rhodopsin-sensitive cGMP 3.5-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene. PDE6D was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase. The precise ...

Phospholipase B

Phospholipase B, also known as lysophospholipase, is an enzyme with a combination of both PLA1 and PLA2 activities, that is, it can cleave acyl chains from both the sn-1 and sn-2 positions of a phospholipid. In general, it acts on lysolecithin.

PIGF

This gene encodes a protein that is involved in glycosylphosphatidylinositol GPI-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serv ...

PIKFYVE

The principal enzymatic activity of PIKfyve is to phosphorylate PtdIns3P to PtdIns3.5P2. PIKfyve activity is responsible for the production of both PtdIns3.5P2 and phosphatidylinositol 5-phosphate PtdIns5P. PIKfyve is a large protein, containing ...

Placental alkaline phosphatase

Alkaline phosphatase, placental type also known as placental alkaline phosphatase is an allosteric enzyme that in humans is encoded by the ALPP gene.

PLEKHM3

Pleckstrin Homology domain containing Family M Member 3, or PLEKHM3, is the hypothetical protein that in humans is encoded by the PLEKHM3 gene. PLEKHM3 is also known as DAPR, and Pleckstrin Homology Domain Containing Family M, Member 1-like.

PMS1

The protein encoded by this gene was identified by its homology to a yeast protein involved in DNA mismatch repair. A role for this protein in mismatch repair has not been proven. However, the protein forms heterodimers with MLH1, a DNA mismatch ...

PNKD

PNKD is the abbreviation for a human neurological movement disorder paroxysmal nonkinesiogenic dyskinesia. Like many other human genetics disorders, PNKD also refers to the disease, the disease gene and the encoded protein. is a protein that in h ...

POLE4

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and pack ...

Poly(a) binding protein interacting protein 2b

Most mRNAs, except for histones, contain a 3-prime polyA tail. PolyA-binding protein PABP, see MIM 604679 enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 MIM 600495 and the polyA ta ...

Pou class 3 homeobox 3

This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system.

PPIL3

This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-foldi ...

PPM1B

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-d ...

PPM1G

Protein phosphatase 1G is an enzyme that in humans is encoded by the PPM1G gene. The protein encoded by this gene is a member of the PP2C family of SER / Tr phosphatase protein. Members of the PP2C family are negative regulators of cell stress re ...

PREB

Prolactin regulatory element-binding protein is a protein that in humans is encoded by the PREB gene. This gene encodes a protein that specifically binds with the Pit1-binding element of the prolactin promoter of PRL. This protein can act as a tr ...

PREPL

Prolyl endopeptidase-like is an enzyme that in humans is encoded by the PREPL gene. PREPL prolyloligopeptidase belongs to a subfamily of serine peptidases Parvari et al. 2005.

PRKAG3

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase AMPK. AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enz ...

PRKCE

Protein kinase C epsilon type is an enzyme that in humans is encoded by the PRKCE gene. PKCε is an isoform of the large PKC family of protein kinases that play many roles in different tissues. In cardiac muscle cells, PKCε regulates muscle contra ...

PRKD3

Serine/threonine-protein kinase D3 or PKC-nu is an enzyme that in humans is encoded by the PRKD3 gene. Protein kinases with PKC is a family of serine-and threonine-specific protein kinases that can be activated by calcium and second messenger dia ...

PRKRA

Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or P rotein ACT ivator of the interferon-induced protein kinase is a protein ...

Prolactin-releasing peptide

Prolactin-releasing peptide is a peptide hormone that in humans is encoded by the PRLH gene. PrRP stimulates prolactin release and regulates the expression of prolactin through binding to the prolactin-releasing peptide receptor.

Protein kinase R

Protein kinase RNA-activated also known as protein kinase R, interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 is an enzyme that in humans is encoded by the EIF2AK2 gene ...

Protein phosphatase 1

Protein phosphatase 1 belongs to a certain class of phosphatases known as protein serine/threonine phosphatases. This type of phosphatase includes metal-dependent protein phosphatases and aspartate-based phosphatases. PP1 has been found to be imp ...