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MAF1

Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene. This gene encodes a protein homologous to Maf1, a Saccharomyces cerevisiae protein which is highly conserved in eukaryotic cells. ...

MAFA (gene)

An in vivo study on mice proved MafA binds to the promoter in an insulin gene to regulate insulin transcription in response to serum glucose levels. MafA is a β cell-specific activator, which differentiates it from other transcription factors inv ...

MAL2 (gene)

Protein MAL2 is a protein that in humans is encoded by the MAL2 gene. This gene encodes a multispan transmembrane protein belonging to the Mal proteolipid family. Protein is a component of lipid rafts and, in polarized cells, it primarily localiz ...

MAPK15

Mitogen-activated protein kinase 15, also known as MAPK15, ERK7, or ERK8, is an enzyme that in humans is encoded by the MAPK15 gene. Evolutionary, MAPK15 remains in some species, including P. troglodytes, B. Taurus, M. Wang, R. norvegicus, D. rer ...

MCM4

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins MCM that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key compone ...

MicroRNA 486-1

microRNAs miRNAs are short 20-24 nt non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymer ...

Mitochondrial ribosomal protein l13

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes mitoribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 7 ...

Mitoferrin-1

Mitoferrin-1 is a 38 kDa protein that is encoded by the SLC25A37 gene in humans. It is a member of the Mitochondrial carrier Superfamily, however, its metal cargo makes it distinct from other members of this family. Mfrn1 plays a key role in mito ...

MMP16

Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene. Proteins of the matrix metalloproteinase of MMP family, is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic ...

MSC (gene)

Musculin is a protein that in humans is encoded by the MSC gene. The protein encoded by this gene is a transcriptional repressor capable of binding e-box element either as a homodimer or as a heterodimer with Е2А in vitro. The encoded protein als ...

MSR1

Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. MSR1 has also been designated CD204.

MSRA (gene)

Msr is ubiquitous and highly conserved. Human and animal studies have shown the highest levels of expression in kidney and liver. It carries out the enzymatic reduction of methionine sulfoxide MetO, the oxidized form of the amino acid methionine ...

MTDH

MTDH AEG-1 is involved in HIF-1alpha mediated angiogenesis. MTDH also interacts with SND1 and involved in RNA-induced silencing complex RISC and plays very important role in RISC and miRNA functions. MTDH has been shown to interact with spliceoso ...

MTMR9

This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar ...

MTUS1

Mitochondrial tumor suppressor 1 or Microtubule-Associated Scaffold Protein 1 is a candidate tumor suppressor protein encoded by the MTUS1 gene in humans. Expression levels of MTUS1 was reported to be lost in various types of human malignancies s ...

MYOM2

M-protein, also known as Myomesin-2 is a protein that in humans is encoded by the MYOM2 gene. M-protein is expressed in adult cardiac muscle and fast skeletal muscle, and functions to stabilize the three-dimensional arrangement of proteins compri ...

N-acetyltransferase 1

N-acetyltransferase 1 is a protein that in humans is encoded by the NAT1 gene. This gene is one of two arylamine N-acetyltransferase NAT genes in the human genome, and orthologous mouse and rat NAT2 genes. The enzyme encoded by this gene catalyze ...

NOV (gene)

NOV is a member of the CCN family of secreted, extracellular matrix ECM-associated signaling proteins see also CCN intercellular signaling protein. The CCN acronym is derived from the first three members of the family being identified, namely CYR ...

ODF1

Outer dense fiber protein 1 is a protein that in humans is encoded by the ODF1 gene. Outer dense fibers are cytoskeletal structures that surround; the axoneme in the middle piece and main parts of the sperm tail. Functions of fiber in maintaining ...

OSR2 (gene)

Protein odd-skipped-related 2 is a protein that in humans is encoded by the OSR2 gene. In mice, it is involved in the development of the palate and in suppressing the formation of teeth after the eruption of adult teeth.

Osteoprotegerin

Osteoprotegerin, also known as osteoclastogenesis inhibitory factor or tumour necrosis factor receptor superfamily member 11B, is a cytokine receptor of the tumour necrosis factor receptor superfamily encoded by the TNFRSF11B gene. OPG was first ...

OTUD6B

OTU domain containing 6B is a protein that in humans is encoded by the OTUD6B gene. OTUD6B is a functional deubiquitinating enzyme class of proteases which specifically cleaves ubiquitin linkages, negating the action of ubiquitin ligase. OTUD6B, ...

PAG1

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene. The protein encoded by this gene is a type III transmembrane protein current, which is associated with the tyrosine ...

PARP10

Poly polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene. PolyADP-ribose polymerases PARPs, such as PARP10, regulate gene transcription by changes of chromatin organization by adding ADP-ribose to histones. PARPs can also func ...

PBK (gene)

Lymphokine-activated killer T-cell-originated protein kinase is an enzyme that in humans is encoded by the PBK gene. The protein encoded by this gene, is a serine / threonine kinase related to the dual specific mitogen-activated protein kinase MA ...

PDE7A

High affinity cAMP-specific 3.5-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene. Mammals possess 21 cyclic nucleotide phosphodiesterase genes that are pharmacologically grouped into 11 families. PDE7A is one o ...

Peptidase inhibitor 15

This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell li ...

Peroxisomal biogenesis factor 2

Peroxisomal biogenesis factor 2 is a protein that in humans is encoded by the PEX2 gene. This gene encodes the composite membrane protein required for peroxisomal the chervyachey peroxisome biogenesis. The protein is thought to be involved in per ...

Phosphatidylserine synthase 1

The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine synthase localizes to the mitochondria-associated membrane of the endoplasmic reticulum ...

PKIA

cAMP-dependent protein kinase inhibitor alpha is a protein that in humans is encoded by the PKIA gene. The protein encoded by this gene is a member of the camp-dependent protein kinase inhibitor of PKA family. This protein was shown to interact w ...

POLR2K

DNA-directed RNA polymerases I, II, and III subunit RPABC4 is a protein that in humans is encoded by the POLR2K gene. This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for RNA synthesis in eukaryotes. ...

POLR3D

DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene. This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. This leads to a block in progression t ...

POP1 (gene)

POP1 is a protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. This protein is a ribonuclease that localizes to the nucleus and ...

PPP2CB

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzym ...

PPP2R2A

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme regulator that in humans is encoded by the PPP2R2A gene.

PPP3CC

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PPP3CC gene. Calmodulin-dependent protein phosphatase calcineurin, is engaged in a wide spectrum of biological activity, acts as ...

PRSS55

This gene encodes a member of a group of membrane-anchored chymotrypsin S1-like serine proteases. The encoded protein is primarily expressed in the Leydig and Sertoli cells of the testis and may be involved in male fertility. Alternate splicing r ...

PSCA (gene)

Prostate stem cell antigen is a protein that in humans is encoded by the PSCA gene. This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed i ...

PTP4A3

Protein tyrosine phosphatase type IVA 3 is an enzyme that in humans is encoded by the PTP4A3 gene. The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases PTPS. PTPS are signaling molecules of the cel ...

PUF60

Poly-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene. The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro Rnps and their interaction is considered to be gain of function for Ro ...

PURG

The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A PURA. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich ele ...

Pyruvate dehydrogenase phosphatase

pyruvate dehyrogenase phosphatase catalytic subunit 1, also known as protein phosphatase 2C, is an enzyme that in humans is encoded by the PDP1 gene. PDPC 1 is an enzyme which serves to reverse the effects of pyruvate dehydrogenase kinase upon py ...

RAB2A

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in v ...

RAB11FIP1

Proteins of the large Rab GTPase family see for example RAB1A have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases. RAB11F ...

RAD21

Double-strand-break repair protein rad21 homolog is a protein that in humans is encoded by the RAD21 gene. The protein encoded by this gene is very similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of d ...

RAD54B

DNA repair and recombination protein RAD54B is a protein that in humans is encoded by the RAD54B gene. The protein encoded by this gene belongs to the dead-like superfamily helicase. It shares similarity with Saccharomyces cerevisiae RAD54 and RD ...

RBPMS

This gene encodes a member of the RRM family of RNA-binding proteins. The RRM domain is between 80-100 amino acids in length and family members contain one to four copies of the domain. The RRM domain consists of two short stretches of conserved ...

RECQL4

ATP-dependent DNA helicase Q4 is an enzyme that in humans is encoded by the RECQL4 gene. Mutations in RECQL4 are associated with autosomal recessive Rothmund-Thomson disease, a syndrome, a disorder that has signs of premature aging. In addition t ...

RGS20

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene. Regulator of G-protein signaling RGS proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins-GTP-ASE-act ...

RHOBTB2

Rho-related BTB domain-containing protein 2 is a protein that in humans is encoded by the RHOBTB2 gene. RHOBTB2 is a member of the evolutionarily conservative of the RhoBTB subfamily of Rho GTPase. Background information on RhoBTBs, see RHOBTB1 M ...